【作者】 陈柏年；

【导师】 杨官娥； 李青山；

【作者基本信息】 山西医科大学 ， 药物化学， 2007， 硕士

【摘要】 槲寄生Viscum coloratum（Kom.）Nakai是桑寄生科槲寄生属植物,在我国分布广泛,尤以北方资源丰富、品种单一。现代药理学研究表明,该属植物具有抗肿瘤、抗心律失常、抗病毒、抗氧化等多种作用。为了进一步寻找槲寄生中的活性化学成分,以便更好地开发和利用这一药用植物资源,本课题对河北承德产槲寄生的化学成分进行了研究。采用乙醇回流提取法得到槲寄生醇提取物,采用硅胶、Sephadex LH-20等柱色谱方法进行分离纯化,从中分离得到16个化合物,利用化学和波谱学方法(IR、MS、¹H-NMR、¹³C-NMR),并与文献报道的相应数据比较,目前已鉴定出12个化合物,它们分别为:黑麦草内酯（loliolide,1）、（+）-表松脂酚[（+）-epipinoresinol,2]、（+）-丁香脂素[（+）-syringaresinol,3]、7,3′,4′-三甲基槲皮素（7,3′,4′-trimthylquercetin,5）、尼克酰胺（nicotinamide,6）、3-表-白桦脂酸（3-epi-betulinic acid,7）、白桦酮酸（betulonic acid,8）、β-乙酰香树脂醇（β-amyrin acetate,9）、β-香树脂醇和羽扇豆醇的混合物（mixture ofβ-amyrin and lupeol,10）、齐墩果酸（oleanolicacid,11）、二十五烷醇（pentacosanol,12）、β-谷甾醇（β-sitosterol,13）。其中化合物1—7和12为首次从槲寄生属植物中分离得到,化合物8为首次从槲寄生Viscum coloratum（Kom.）Nakai中分离得到。此研究为进一步有效、合理开发利用槲寄生奠定了基础。更多还原

【Abstract】 Viscum coloratum（Kom.）Nakai,which belongs to genus Viseum of the Loranthaceae family,is distributed widely across our country,especially in Northern China.According to the modern pharmacological research,the plants of genus Viscum show several kinds of medicinal effects,such as antitumor;antiarrhythmia,antivirus,antioxidation,etc.In order to find the pharmacological-active compounds of mistletoe,exploit and utilize this medicinal plant resource,the studies on chemical constituents of Viscum coloratum（Kom.）Nakai growing in Chengde,Hebei province were carried out.The mistletoe alcohol extracts were obtained by refluxing with 75%ethanol, which were further separated and purified through silica gel and Sephadex LH-20 chromatography and 16 compounds were got.Among them 12 compounds isolated from mistletoe were characterized by chemical reaction,IR,MS,¹H-NMR and ¹³C-NMR,along with comparing the data with those reported in literatures.The compounds identified as follows: loliolide（1）,（+）-epipinoresinol（2）,syringaresinol（3）,7,3’,4’-trimthylquercetin（5）,nicotinamide （6）,3-epi-betulinic acid（7）,betulonic acid（8）,β-amyrin acetate（9）,mixture ofβ-amyrin and lupeol（10）,oleanolic acid（11）,pentacosanol（12）,β-sitosterol（13）.Compounds 1-7 and compound 12 were obtained from genus Viscum for the first time,compound 8 was obtained from Viscum eoloratum（Kom.）Nakai for the first time.These studies were useful for the further research and development of mistletoe.更多还原