三维旋转磁场定位仪磁场空间分布研究

【作者】 傅伟；

【导师】 熊平；

【作者基本信息】 中南大学 ， 生物信息物理学， 2007， 硕士

【摘要】 肿瘤靶向定位治疗是目前医学界研究的热点和难点问题。靶向定位的载体目前主要有抗体载体、配体载体、活性多肽载体等，定位原理都是基于生物学特性进行组织的，每一种载体对药物定向带有很大的选择性，都只针对特定的肿瘤治疗有效。本文提出利用纳米铁作为载体，在三维旋转磁场的作用下定位到肿瘤病灶部位进行靶向治疗，对三维旋转磁场定位仪的磁场空间分布作了详细的研究。将纳米铁有效地定位到病灶部位，关键是要在病灶部位形成一个强磁场区域，达到纳米铁汇集的条件。针对上述难点，本文主要作了以下几方面的工作：(1)对目前肿瘤靶向治疗国内外研究现状进行了叙述，并提出利用纳米铁作为肿瘤靶向治疗的载体。(2)介绍了电磁场的基本理论，并设计出三维旋转磁场定位仪的模型，阐述了三维旋转磁场定位原理。(3)利用MathCAD软件计算各种条件下磁场的大小及其变化规律，应用ANSYS软件建立有限元模型进行磁场模拟，并探讨出三维旋转磁场定位仪设计的工艺参数。(4)研制三维旋转磁场定位仪微缩模型，以此验证模拟结果。三维旋转磁场的模拟结果以及微缩模型的实际结果，均取得了良好的效果，为三维旋转定位治疗仪投入工业化生产提供了理论依据。更多还原

【Abstract】 Tumor target oriented therapy is medicinal research hotspot and difficulty at present. Target oriented carrier at present primary contains antibody carrier, conjugant and active amylase carrier. Oriented principle is based on biology specialty. Every carrier is selective for drug orientation. It is effective for specifically tumor therapy. This paper puts forward nanometer-iron particles as drug carriers. These carriers can orientate to tumor focus by effect of the 3D rotated magnetic field. This paper is absorbed in studying of the distributing of the rotated 3D magnetic field.In order to orientate the drug carrier to tumor focus, it need form insensitive magnetic field, satisfies the condition of the nanometer-iron particles influx. In order to solve the problem this paper sets forth following study:(1) This paper depicts the study of tumor target orientated therapy at domestic and overseas at present, and then brings forward nanometer-iron particles as drug carrier.(2) This paper introduces the principle of the electromagnetic field, then designs out the model of the 3D rotated magnetic field and explains the orientated theory of the 3D rotated magnetic field.(3) This paper achieves the magnetic field intensity and the variety law at various conditions by the MathCAD soft, builds the model of finite element and simulates magnetic field, educes the appropriate technique parameter.(4) This paper manufactures the tiny model apparatus of the 3D rotated magnetic field in order to prove the simulated result.The simulated result and tiny model apparatus result are all perfect. These results provide the theory for the therapy apparatus manufacture.更多还原