何学红教授以肾衰方治疗慢性肾功能衰竭63例临床观察与疗效分析

【作者】 马秀宁；

【导师】 何学红；

【作者基本信息】 辽宁中医药大学 ， 中医内科学， 2007， 硕士

【摘要】 目的：观察肾衰方治疗慢性肾功能衰竭的临床疗效。方法：63例慢性肾功能衰竭患者，均选择尿毒症期之前的病例，将其随机分为治疗组(32例)，对照组(31例)，其中治疗组在常规治疗基础上进行中医辨证分型，以肾衰方为基本方根据不同证型加减应用，对照组在常规治疗基础上加用析清胶囊，观察比较两组在改善临床症状、生化指标等方面的疗效差异。结果：治疗组总有效率87.50％，明显高于对照组61.29％(P＜0.05)；治疗组在降低血清肌酐(Scr)和血尿素氮(BUN)，提高内生肌酐清除率(Ccr)方面，均优于对照组(P＜0.05)。治疗组在改善临床主要症状方面也优于对照组(P＜0.05)。结论：通过中医辨证，以肾衰方为基本方结合常规疗法治疗慢性肾功能衰竭，能有效改善生化指标，改善临床症状，对于进入尿毒症期之前的患者疗效优于对照组。更多还原

【Abstract】 Objective: To observe the clinical effect of Shenshuaifang inpatients with chronic renal failure(CRF).Methods: Select 63 patients with CRF who are all before intouremia stage, and divide them into treatment group and contrast groupat random, treatment group is 32 case and contrast group is 31 case.Patients of treatment group take routine treatment and Shenshuaifang,according to the different types in traditional Chinesemedicine(TCM); Patients of contrast group take routine treatment andXiqing capsule. Then observe and compare the difference of treatmenteffect in improving the test data and clinical symptoms during thetwo groups.Results: The overall therapentic efficiency of treatmentgroup(87.50％) is much better than that of contrast group(61.29％)(P＜0.05). The analysis of correlation shows that the treatment groupis significantly better than contrast group in decreasing serumcreatinine(Scr),Blood urea nitrogen(BUN), and in increasingclearance of endogenous creatinine(Ccr)(P＜0.05).Treatment groupis much better than contrast group in improving clinical symptoms(P＜0.05).Conclutions: Through selection of treatment based on thedifferential diagnosis, appling Shenshuaifang and combinatingroutine treatment to CRF can improve renal function and clinicalsymptoms. To the patients who aren’t into uremia stage the clinicaleffect of Shenshuaifang is better than contrast group.更多还原