【作者】 张强；

【导师】 李彦冰；

【作者基本信息】 黑龙江中医药大学 ， 药物分析学， 2007， 硕士

【摘要】 焦虑泰康饮是由黄连12g、黄芩6g、白芍6g、阿胶9g四味药所制成的颗粒剂。功效滋阴清热，交通心肾，主要用以治焦虑症，缓解阴虚、火旺、心烦不寐、咽干口燥等症状。本课题以中医药理论为指导，对焦虑泰康饮配方颗粒进行了临床前药学部份的研究。对成型工艺进行考察，采用薄层色谱法对焦虑泰康饮中黄连、黄芩、白芍三味药进行薄层鉴别；采用高效液相色谱法对焦虑泰康饮中所含盐酸小檗碱和黄芩苷进行含量测定，以制定焦虑泰康饮的质量标准。实验结果显示：焦虑泰康饮颗粒中黄连、黄芩、白芍三味药的薄层鉴别，方法简便，快捷，分离效果好，重现性好，专属性强；以高效液相色谱法测定焦虑泰康饮中盐酸小檗碱和黄芩苷的含量，实验结果表明盐酸小檗碱在0.033728～0.16864ug范围内呈良好的线性关系，平均回收率为100.54％，变异系数为1.54％；黄芩苷在0.04976～0.2488ug范围内呈良好的线性关系，平均回收率为99.98％，变异系数为1.20％，二者的含量测定可作为焦虑泰康饮质量控制的量化指标。更多还原

【Abstract】 Granula for antianxiety and tranquilizing consists of huanglian(Coptis chinensis Franch)、huangqin(Scutellaria baicalensis Georgi)、baishao(Paeonia Llactiflora Pall.)、ejiao(Equus asinus L.), and has the function of nourishing yin and heat-clearing, restoring normal coordination between heart and kidney, therapying anxiety disorders, relieving asthenic yin causing excessive pyrexia as well as upsetting and hyposomnia, and dry throat etc.Under the guidance of the theories of TCM, Granula for antianxiety and tranquilizing has been researched on pre-clinical pharmacy. Moulding conditions were screened. The technique of TLC was used to identify Coptis chinensis Franch, Scutellaria baicalensis Georgi, Paeonia Llactiflora Pall., The contents of berberine hydrochloride and baicalin were determined by HPLC. The quality standard was built up on the basis of TLC and HPLC.Results: the identification by TLC is fast and convenient; the effect is satisfying; the reproducibility is; steady ; the specificity is good. Berberine hydrochloride showed good linear relationship in the range of 0.033728～0.16864ug. The average recovery was 100.54%, RSD 1.54%. Baicalin showed good linear relationship in the range of 0.04976～0.2488ug. The average recovery was 99.98%, RSD 1.20%. The results can become the quantity index of qualify control on Granula for antianxiety and tranquilizing.更多还原