【作者】 赵大鹏；

【导师】 宋立群；

【作者基本信息】 黑龙江中医药大学 ， 中医内科学， 2007， 硕士

【摘要】 目的：通过运用滋阴潜阳、活血通络法治疗高血压病肾损害患者的临床研究，观察自拟方降压保肾汤的临床疗效。方法：将60例符合标准的高血压病肾损害患者随机分为治疗组30例，对照组30例。治疗组在常规西药的基础治疗上加用降压保肾汤治疗，对照组在常规西药的基础治疗上加用肾炎康复片，8周为一个疗程，观察治疗前后患者偶测血压（CBP）、24小时动态血压检测（ABPM）、尿β₂-微球蛋白（β₂-MG）、尿液分析、血细胞分析等指标，并记录两组主要症状的变化，做出疗效评价。结果：治疗组与对照组的总疗效及中医证候总疗效比较有显著性差异（P＜0.05），治疗组优于对照组。治疗组不仅能明显降低血压，而且能显著降低尿微量蛋白的排出量，疗效明显优于对照组（P＜0.05）。同时，能改善患者全身症状。结论：运用滋阴潜阳、活血通络法，自拟降压保肾汤能够明显改善临床症状，可以有效的改善患者24小时血压水平、明显的降低尿微量白蛋白的排出量。自拟降压保肾汤是治疗高血压病肾损害的一组有效药物，与常规西药合用疗效更佳。更多还原

【Abstract】 Objective: The goal of this clinical research is to probe the mechanism and therapeutic effect of jiang ya bao shen tang on treating renal damage in essential hypertension by nourishing yin , suppressing yang , promoting blood circulation and remove meridian obstruction.Methods: Sixty patients of renal damage in essential hypertension were divided into curative group (30cases) and control group (30cases) at random. The curative group was treated by decoction for jiang ya bao shen tang and regular western medicine, while the control group was treated by regular western medicine and shen yan kang fu pian. Eight weeks was a course of treatment. The changes of blood pressure and urinary microalbumen were observed before and after treatment. Furthermore, we should record the changes of symptoms between the curative group and the control group, and evaluate curative effects.Results: There are remarkable differences between the two groups on chief curative effects. The effect of the curative group is much better than that of the control group (p<0.05). The curative group can not only lower blood pressure obviously, but lower urinary microalbumen excretion significantly as well. The effect of the curative group is much better than that of the control group obviously (p<0.05). Meanwhile, the curative group can also improve general symptoms.Conclusion: jiang ya bao shen tang can improve clinical symptoms markedly. It has good effects on lowering blood pressure and urinary microalbumen excretion. jiang ya bao shen tang is a group of effective drugs on treating renal damage in essential hypertension. If combined with regular western medicine, the effect will be much better.更多还原