【作者】 张晓艳；

【导师】 孙伟正；

【作者基本信息】 黑龙江中医药大学 ， 中医内科学， 2007， 硕士

【摘要】 目的：通过应用紫癜清治疗过敏性紫癜(HSP)的临床研究，观察紫癜清治疗HSP的临床疗效，探讨紫癜清治疗HSP时对血清sVCAM-1水平的影响。方法：将确诊为HSP的患者按开放方式分为两组，试验组30例，对照组28例，试验组用紫癜清颗粒，对照组用强的松，疗程为30天，观察2个疗程。观察比较两组治疗前后在临床症状消失所需时间与血清sVCAM-1水平方面的差异。结果：(1)紫癜清试验组与强的松对照组总疗效相比无显著性差异(p＞0.05)，试验组的治疗效果与对照组相近。(2)紫癜清试验组在改善蛋白尿方面与强的松对照组相比，二者有显著性差异(p＜0.05)，在改善其他各型症状方面与强的松对照组相比，二者无显著性差异(p＞0.05)。(3)紫癜清无明显毒副作用，服用强的松的患者则存在中医方面和西医方面的副作用。(4)紫癜清试验组在调节sVCAM-1水平方面与强的松对照组相比，二者无显著性差异(p＞0.05)。结论：紫癜清能有效改善HSP患者的临床症状，尤其是对蛋白尿的改善疗效显著，能降低患者sVCAM-1的表达水平，且因其无皮质类固醇激素的副作用，故可代替激素长期使用以治疗HSP。更多还原

【Abstract】 Objective: The goal of this clinicial experiment is to observe the clinical effect of ZiDianQing in treating Henoch-schonlein purpura and probe the effect on the level of sVCAM-1 .Methods: 58 patients with HSP were divided into 2 groups openly:the experiment group was 30 cases,the control group was 28 cases.the ZiDianQing treatment was given to the experiment group, the Prednisone treatment was given to the control group, the course of treatment is 30 days.we need to observe 2 courses of treatment.we compared the difference of the time which clinical symptoms’ disappearance need and the level of sVCAM-1 in serum before and after treatment between the two group.Result:(1)The curative effects in the experiment group were similar to those in the control group(p> 0.05).(2)The experiment group has an evident improvement in protein in urine,the improvement of other symptoms is no better than the control group. (3)ZiDianQing has no side-effect of Henoch-schonlein Purpura treated by Prednisone.(4)The experiment group can regulate the level of sVCAM-1. the same was true of the control group(p>0.05).Conclusion: ZiDianQing can be effective against the patients’ clinical symptoms,especially against protein in urine and decrease the level of sVCAM-1,but it has no side-effect of hormone,so it uses to cure patients of Henoch-schonlein purura long instead of hormone.更多还原