【作者】 高宗慧；

【导师】 刘迎；

【作者基本信息】 天津大学 ， 光学， 2006， 硕士

【摘要】 生物组织中光的传输和生物组织光学特性的研究是组织光学领域中重要的基础的研究工作。通过对生物组织的漫反射光分布的研究,可以获知表征组织生理特性的光学参数,这样可以为临床的医疗诊断和治疗提供参数指标,对医学领域的相关应用有重要的指导意义。P3近似理论是描述光源附近空间分辨漫反射的理论模型,本文P3在近似理论的基础上,讨论了组织光学参数吸收系数μa、有效散射系数μ’s、二阶参数γ和三阶参数δ灵敏度对空间分辨漫反射的影响,结果表明,光学参数的灵敏度P3对近似空间分辨漫反射的影响程度和区域不同。在以上理论研究的指导下,采用双光纤测量装置进行了光源附近空间分辨漫反射的实验研究,做了实验器件的性能分析和实验系统的调试,以组织模拟液Intralipid和吸收体亚甲基兰为实验样品,配制成不同浓度的模拟液,研究了散射特性和吸收特性对空间分辨漫反射的影响,并将实验结果与P3近似的理论结果做比较,研究表明,实验结果与理论分析的趋势相一致。在以上实验研究的基础上,进行了实验装置的进一步改进,自主设计并完成制作了微型阵列式光纤探头,可用于光源附近0.3-3.6mm区域的漫反射实验研究,并对其做了通道性能的测试,结果表明通光性能良好;研究设计了多通道实验测量系统的方案,对实验器件进行了性能研究和初步的调试。更多还原

【Abstract】 The studies of light propagation in biological tissue and tissue optical parameters are important and fundamental. The optical parameters which characterize the physiological properties of the tissue can be gained by analyzing the spatially resolved reflectance from the tissue. The optical parameters of tissue supplies the index parameters for clinical therapy and diagnose, has great instructional significance for the application in medical.P₃approximation theory describes the spatially resolved reflectance near the source. The effects of optical parameters including absorbing coefficientμa, efficient scattering coefficientμ’s , the second-order parameterγand the third-order coefficientδon the diffused reflectance are studied, and the results show the influences are different in the region and extent.Based on the study of the P3 approximation theory, double-fibers equipment has been used in the experiment. The devices performance has been analyzed and debugged. We studied the effects on the distribution of reflectance by absorbing and scattering using the sample with different concentration made of Intralipid and Methylene blue, the results compared with P3 approximation show the same trend.Based on the experimental facility above, we designed and manufactured a linear array fibers probe, and tested its propagation characteristic were good. It can be used in the experiment to study the spatially resolved reflectance in the region of 0.3-4.2mm. The experimental system has been further studied, the multi-channel experimental system was designed, and the performance parameter of the components been studied.更多还原