中药对大鼠极限性肝叶切除早期残肝功损害的影响

【作者】 陈斌；

【导师】 唐天勋；

【作者基本信息】 南京中医药大学 ， 中医外科学， 2006， 硕士

【摘要】 目的：探讨丹参和川芎嗪针剂对大鼠极限性肝叶切除后早期残肝损害的效应。 方法：建立大鼠90％极限性肝叶切除模型，分别观察丹参和川芎嗪对大鼠手术后死亡率，残肝HE染色肝细胞中央静脉及汇管区的改变以及术后血生化的改变。 结果：丹参和川芎嗪针剂均能不同程度的减轻早期残肝细胞肿胀及汇管区的炎性反应，但均不能改善实验动物的死亡率。 结论：丹参和川芎嗪针剂可能通过改善残肝的微循环以减轻极限性肝叶切除后残肝的损害，但并不能促进残肝细胞的再生，从而延长动物的存活。更多还原

【Abstract】 Objective: To observe the effects of the traditional Chinese medincine (labiatae and tetramethylpyrazine ) on the residual liver function and the survival time of the rats with excessive hepatectomy.Methods: After successfully setting up the model of 90% excessive hepatectomy in rats , the mortalities after the rat’s operation, the pathologic changes of the residual liver central vein and portal area with the treatment of labiatae and tetramethylpyrazine and biochemical change of blood were observed.Results: The degrees of injury of the residual liver with the treatment of labiatae and tetramethylpyrazine were decreased , without decreasing the morality of the experiment animol.Conclusion: The injury of the early residual liver cell after the injection of labiatae and tetramethylpyrazine can be lightened. These medicines can not promote the residual liver cell’s regeneration and prolong the survive time after excessive hepatectomy.更多还原