【作者】 李剑芳；

【导师】 崔征；

【作者基本信息】 沈阳药科大学 ， 生药学， 2006， 硕士

【摘要】 怀槐Maackia amurensis Rupr. et Maxim.,又名山槐、高丽槐、朝鲜槐，是豆科(Leguminosae)马鞍树属(Maackia)植物。怀槐具有抗氧化、抗辐射、抗肿瘤及抗炎等作用，民间用来治疗跌打损伤、瘀血肿痛、风湿性关节炎、溃疡等症。 本论文对怀槐树皮70％乙醇提取物的乙酸乙酯萃取部分进行化学成分的研究，经反复硅胶柱色谱，Sephadex LH-20和重结晶等手段从怀槐中分离得到17个化合物，根据化合物的理化性质、波谱数据及与对照品和文献数据对照鉴定了其中14个化合物的化学结构，分别为：鸢尾种苷元(MAE2, tektorigenin)、染料木素(MAE3, genistein)、阿夫罗摩辛(MAE4, afromosin)、樱黄素(MAE5, prunetin)、芒柄花黄素(MAE6,formononetin)、ononin 6"-O-acetate(MAE7)、maackiaflavanone(MAE8)、maackiain3-O-(6’-O-malonyl-β-D-glucopyranoside)(MAE10)、maackiain 3-O(6’-O-acetyl-β-D-glucopyranoside)(MAE11)、di-O-methyldaidzein(MAE12)、maackiain(MAE13)、β-谷甾醇(MAE15，β-sitoterol)、鸢尾种苷(MAE16，tectoridin)和afromosin 7-O-β-D-glucopyranoside(MAE17)。 其中化合物MAE5、7、10和11均为首次从该属植物中分离得到，化合物MAE8、12和13均为首次从该植物中分离得到。更多还原

【Abstract】 Maackia amurensis Rupr. et Maxim., the plant of Leguminosae, has the antioxidant, antiradical, antitumour and anti-inflammation activities, being used to treat injuries from falls, bruise and gall, rheumatoid arthritis, ulcer and so on.Seventeen compounds were separated from the EtOAc fraction of 70% ethanol extraction of M. amurensis by repeated silica gel column chromatography, Sephadex LH-20 column chromatography, recrystallization and so on.Fourteen compounds’ structures were identified on the basis of their physico-chemical properties and spectroscopic analysis. The compounds are shown as follows: tectorigenin(MAE2), genistein (MAE3), afromosin(MAE4), prunetin(MAE5), formononetin (MAE6), ononin 6"-O-acetate (MAE7), maackiaflavanone (MAE8), maackiain 3-O(6’-O-malonyl-β-D-glucopyranoside) (MAE10), maackiain 3-O-(6’-O-acetyl-β-D-glucopyranoside) (MAE11), di-O-methyldaidzein(MAE12), maackiain (MAE13), β-sitosterol (MAE15), tectoridin (MAE16) and afromosin 7-O-β-D-glucopyranoside (MAE17). Compounds MAE5, 7, 10 and 11 were isolated from this genus for the first time, and compounds MAE8, 12 and 13 were isolated from this species for the first time.更多还原