【作者】 张彬；

【导师】 陈泽涛；

【作者基本信息】 山东中医药大学 ， 中西医结合临床， 2006， 硕士

【摘要】 目的：通过观察以益气活血为主要治法对老年高血压颈动脉粥样硬化病变患者血脂、血管活性物质、颈总动脉内膜中膜(IMT)、颈总动脉血流量以及临床症状的干预，论证益气活血法是治疗老年高血压颈动脉粥样硬化病变的基本治疗方法。方法：采用分层随机分组法将患者分为益气活血研究组28例和对照组24例，2周为一疗程，共进行3个疗程。结果：统计学资料显示，研究组在调节血脂、调节血管活性物质、降低颈总动脉IMT、增加颈总动脉血流量、改善临床症状以及防治辛伐他汀肝损害等方面均明显优于对照组，并有统计学意义。结论：通过多环节、多机制、多靶点综合作用，研究组有效的延缓了老年高血压颈动脉粥样硬化病变的进程，改善了临床症状，而且有效地防治了辛伐他汀肝功能损害。提示益气活血法是治疗老年高血压颈动脉粥样硬化病变的有效的基本治疗方法。更多还原

【Abstract】 Objective: To observe the clinic effect of the integration of traditional and western medicine in curing Senile Hypertensive Disease complicated with Carotid Atherosclerosis by using the Chinese traditional medicine combination of supplementing qi and activating blood, to discuss the effecting mechanism and the effecting target. And to reasoning the basic disease mechanism of senile hypertensive disease coincidenced with carotid atherosclerosis is qi deficiency and blood stasis. Method: All suffers were grouped by statistic through delaminating and disparted into two troops. One is used the Chinese traditional medicine combination of supplementing qi and activate blood and simvastatin, another simvastatin only. Resolute: There are outstanding evident differences between the two troops. The investigating troop is better in many aspects, such as adjusting the blood fat, the vasoactive substances, depressing carotid intima-media thickness, subsidising the carotid atheromatous plaque and improving the clinic symptom, and all has statistics meaning. Conclusion: The Chinese traditional medicine combination of supplementing qi and activate blood of Huang Qi Injection Xiang Dan Injection this research choosed operated through many taches, many mechanisms and many targets, which efficiently stayed the course of senile hypertensive disease complicated with carotid atherosclerosis. So, we can say that this combination is a better combination in the therapy of senile hypertensive disease complicated with carotid atherosclerosis更多还原