【作者】 易韬；

【导师】 丁宪群；

【作者基本信息】 贵阳中医学院 ， 中医外科学， 2006， 硕士

【摘要】 目的：观察中医清泻法对梗阻性黄疸内毒素血症的疗效。方法：将大鼠分为4组，即模型组、模型对照组、空白组，模型组分为清泻法组和西药组，模型组、模型对照组开腹胆总管结扎法造模，空白组仅游离牵拉胆总管即可，不结扎。模型组灌喂实验制剂。实验结束后，检测各组大鼠血浆中内毒素、TNF-α、肝功能，并制作肝脏病理切片。依据实验数据，分析清泻法对梗阻性黄疸内毒素血症大鼠内毒素、TNF-α等的影响。结果：梗阻性黄疸内毒素血症大鼠经清泻法自拟汤治疗后，毛色、性隋等一股情况较模型对照组有一定改善，而日均饮水量有明显提高(P均＜0.05)，可降低各项实验室指标，各指标明显低于模型对照组(P均＜0.01)。对TNF指标的改善优于西药组(P＜0.05)，其他疗效指标与西药组相比疗效相近(P均＞0.05)，且总体指标改善情况有高于后者之倾向，表明清泻法自拟汤对梗阻性黄疸内毒素血症治疗有效，疗效有优于西药乳果糖对照组之趋势。结论：中医清泻法治疗梗阻性黄疸内毒素血症安全有效。更多还原

【Abstract】 Objective: To observe the effects of the Febricide and Catharsis Treatment of Chinese Medicine (FCTCM) to the Obstructive Jaundice Endotoxemia (OJE). Method: Experimental rats were divided into 4 groups: the Model Group (which also falls into two groups: one was treated with FCTCM and the other with the western medicine), the Model Control Group and the Blank Group. Make a mold through ligating the common bile duct of the Model Group and the Model Control Group rats. While, to the Blank Group rats, just pulled the common bile duct loosely, not to tie them up. Feeded the Model Group rats with experimental preparation-food. After the experiments ended, we examined the indexes of blood plasma endotoxin, TNF - α and the liver function of the rats in each group respectively, and manufacture their liver pathological slices. And analyzed the effect of the FCTCM treatment to the Obstructive Jaundice Endotoxemia of the rats including their TNF - α based on the experimental data. Results: After treated by the Febricide and Catharsis Treatment of Chinese Medicine, the rats, which are with the Obstructive Jaundice Endotoxemia, have improved their quality of fur color and temper, they obviously drinked more water daily than usual (P < 0.05), which droped each experiment index compared with the rats in the Model Contrast Group (P < 0.01). They also had a better improvement of TNF compared with the ones in the western medicine group (P < 0.05). They had got almost exact treatment effects (P > 0.05) of the rest experiment indexes and had got a much better improvement tendency to the rats in the western medicine group. All that indicates the FCTCM was not only effective to the treatment of the Obstructive Jaundice Endotoxemia, but also it was superior to the treatment for the rats in the Model Contrast Group with western lactose medicine. Conclusion: It is safe and effective to apply the FCTCM to the treatment for the Obstructive Jaundice Endotoxemia.更多还原