【作者】 叶林；

【导师】 冯作山； 李国强；

【作者基本信息】 新疆农业大学 ， 食品科学， 2006， 硕士

【摘要】 阜康阿魏(Ferula fukanensis K. M. Shen)为药典收载品种，具有杀虫、消积、除痞等作用。文献调研表明其化学成分研究未见报道，为了研究其化学成分，完善和提高该常用中药的质量标准，并为药效药理奠定物质基础，我们为此进行了较系统的化学成分研究。从该植物的低极性部分中分离得到了7种化学成分，通过NMR、MS、IR、UV等光谱分析和理化常数比较，鉴定了7个化合物，其中甾体及其苷类2个，萜类化合物1个，芳香酸酯1个，香豆素类化合物1个，葸醌2个，其中2种化合物为本属中首次发现。通过对其化学成分的系统研究为开发研究新药及提高其质量标准打下了良好的物质基础。 豆叶霸王(Zygophyllum fabag)隶属于蒺藜科(Zygophyllaceae)驼蹄瓣属(Zygophyllum L.)，具有祛热抗炎，降低血糖，抗高血压，止腹泻，抗菌等功效。文献调研表明其化学成分研究未见报道，我们对其进行了较系统的化学成分研究。从该植物中分离鉴定了7种化学成分，它们分别是豆甾-4-烯-3-酮(stigrnast-4-en-3-one)，3-O-[β-D-glucopyranosyl]-quinovic acid，紫云英苷(astragalin)，β-谷甾醇(β-sitoster01)，胡萝卜苷(daucoster01)，正二十八烷醇n-noctacosanol，正三十二烷醇n-dotriacontanol。 此外，本文还综述了阿魏属和驼蹄瓣属植物的化学和药理学研究进展。更多还原

【Abstract】 Ferula fukanensis, as an important drug collected in Chinese Pharmacopoeia, has been widely used to treat inflammation, dyspepsia and infection in many countries and districts. In order to study the chemical constituents and develop a more efficient quality control project, 7 compounds were isolated from the low polarity part of the 95% EtOH extract of Ferula fukanensis, from them, 7 compounds were structurally identified by means of various modern spectroscopic techniques (NMR, MS, IR.UV and so on ) and on the basis of their physical properties. Among them, two were isolated in the genus Ferula for the first time. The chemical work provided a material base for the quality control and new drug development.Zygophyllum fabag belongs to the family Zygophyllaceae, the genus Zygophyllum, has been widely used to anti-infammatory, antipyretic, antidiarrhoeal, antihypertensive and lowwing blood glucose. In order to study the chemical constituents and develop a more efficient quality control project, 7 compounds were isolated from the 95% EtOH extract of Zygophyllum fabag. The structures of them were elucidated as follows: stigmast-4-en-3-one, 3-O-[β-D-glucopyranosyl] -quinovic acid, astragalin,β-sitosterol. daucosterol, n-noctacosanol, n-dotriacontanoL.This thesis also reviewed advances of the chemical and pharmacological studies of the genus Ferula and the genus Zygophyllum.更多还原