【作者】 张英；

【导师】 黎洪生；

【作者基本信息】 武汉理工大学 ， 控制理论与控制工程， 2006， 硕士

【摘要】 生化分析仪的出现大大改变了原来由于采用手工生化分析而导致的操作繁琐,受操作者主观因素影响大,错误几率大的状况。我国医疗器械产品总体水平落后,国内生化实验室采用的基本是进口产品。因此开展自动生化分析仪的研究,对提高我国生化分析仪器的研究和设计水平具有一定的意义。本设计旨在开发操作方便,功能完善的小型半自动生化分析仪。该生化分析仪仅供体外诊断使用,主要用来对人的血液和其他体液中的各种生化指标进行分析,通过光电法测定待测物浓度。主要研究内容如下: 通过了解生化分析原理和生化测试基础,根据生化分析仪所要达到的性能指标,设计生化分析仪控制系统的总体结构,对硬件和软件功能做出明确和合理的分配。 以MSP430F149单片机为核心,实现了生化分析仪的硬件系统。完成硬件平台,接口模块、信号调理模块的开发设计,并使该硬件平台具有一定的抗干扰能力。利用光电法进行信号检测,并设计了自动增益信号调理电路,改善了低浓度试剂信号的信噪比,提高了生化分析仪的检测精度。 完成生化分析仪的软件设计。用C语言进行软件程序的编制。按照系统功能要求,设计了串行通信模块、显示模块、键盘处理模块、A/D转换模块、数据处理模块等。各个模块部分的内容相互独立,便于程序编写和调试。 生化分析仪在检测过程中,要求试样处于恒温条件,温度控制方面的因素对仪器的分析性能也有较大影响,本设计采用模糊控制算法,用数字式温度传感器测温,用MSP430F149作为控制器,构成闭环温度控制系统。该方法控制动态性能好、稳定性强。 本文设计的生化分析仪已经过系统的联机调试,运行稳定、结果正确,表明系统的设计是合理的、可靠的。本设计顺应了医疗仪器国产化的发展趋势,随着仪器的开发完成与推向市场,必将产生良好的社会效益与经济效益。更多还原

【Abstract】 Since the introduction of the traditional manual biochemical analysis may lead to sophisticated operation, the great effect from the operators’ subjective factors, and the serious error, the appearance of the biochemical analyzer changes this situation significantly. Because the overall level of domestic medical equipments are not so satisfactory, biochemical laboratories mainly use imports. Therefore, the study on automatic biochemical analyzer has a great significance of enhancing our level in researching and designing biochemical analyzer. This project is conceived to design a small semi-automatic biochemical analyzer, which is easy to be used with improved functions . The biochemical analyzer is mainly used for exosomatic diagnosis to analyses the various biochemical guide line of blood and other body fluids, it mensurates concentration of objects by photovoltaic method. Main research content is as follows:Studying through the principles of biochemical analysis and the basis of biochemical test, and according to the performance indicators of the biochemical analyzer to be achieved, the architectures of control system of the biochemical analyzer is designed, and a clear and reasonable distribution for the hardware and software functions is made.The hardware system of biochemical analyzer with the MSP430F149 as the core is realized. Signal detection was achieved by using photovoltaic method, and an automatic gain signal conditional circuit was designed to increase low-concentrations reagents signal-to-noise ratio, and improved the detection accuracy of the biochemical analyzer.The design of the software of the biochemical analyzer has been finished based on IAR Embedded Workbench for debugging development. According to the system functional demand, the serial communication module, display module, keyboard module, A/D conversion module and data processing module are designed.In the course of testing, specimen should stay at the constant temperature conditions, temperature control has a greater impact on the performances of the biochemical analyzer, the design control algorithms adopts fuzzy theory, use digital temperature sensors, and use MSP430F149 as MCU to form a closed loop temperature control system. By this means, the system achieved a good dynamic performance and well stability.The design of biochemical analyzer has been adopted online system debugging, it can run stably, and the result is correct, so the system design is reasonable and reliable. The design conforms to the trends of medical equipment domestically, and with the completion of the development of the analyzer and being market, it is bound to have good social and economic benefits.更多还原