【作者】 王士彬；

【导师】 孙才新；

【作者基本信息】 重庆大学 ， 电气工程， 2005， 硕士

【摘要】 实验和理论研究初步证实,细胞膜的电穿孔程度(包含穿孔可逆或不可逆)与施加电脉冲的多个特征参数相关。为了更深入地研究电脉冲作用于细胞膜的内部机制,满足目前临床试验和应用的要求,有必要研制一套参数调节灵活、输出稳定、监测方便并能用于肿瘤细胞发生不可逆电穿孔试验研究的高压陡脉冲肿瘤治疗系统。 本论文在交流一直流功率转换电路的基础上,提出一种基于数字信号处理器的电脉冲参数控制和测量一体化方案。结合现场可编程门阵列和其他电子元器件,设计并实现的高压陡脉冲肿瘤治疗系统不仅能对系统输出的电压幅值、上升时间、下降时间、重复频率和脉冲宽度等参数进行在线监测,而且可对上述部分参数进行闭环控制,保持输出的稳定性。文中详细介绍了功率转换电路PWM控制的基本原理和频率差值倍增技术的具体方法,简要阐述了液晶显示电路、日历时钟模块和电容切换电路的控制策略,重点探讨了电压幅值测量模块、上升时间和下降时间测量模块、电压幅值控制模块及键盘接口电路、RS-232通信等电路的设计依据、结构和功能。此外,还介绍了对电压幅值测量模块、上升时间和下降时间测量模块进行仿真的过程和结果。本论文采用了典型的前后台模式的软件组织形式,以主程序作为后台任务,中断服务程序作为前台任务,通过对前后台任务的快速切换和优先级排序,达到及时响应测量、控制和显示等一系列任务的目的。 本论文对设计完成的高压陡脉冲肿瘤治疗系统进行了测试和校正,通过对测量模块、控制模块和显示模块等的检验和调试,以及系统整机联调和带负载测试,对测试结果进行了分析,表明本论文提出的设计方案和实现方法能够满足使肿瘤细胞不可逆电击穿机理研究及临床试验和应用的需要,达到了预期设计目标。更多还原

【Abstract】 It has been validated that cell membrane electroporation, including reversible and irreversible electropermeabilization occurred, when it was exposed to high intensity electric pulse. And the electroporation degree has relation to many pulse characteristic parameters. For deeper research on the inner inter-mechanism of electric pulse and cell membrane, it’s essentially to develope a set of high voltage steep pulse tumor treatment system, whose parameters can be set agilely, exported stably, monitored conveniently.This paper brings forward a pulse parameters controlling and measuring integrative scheme based on Digital Signal Processor. The high voltage steep pulse tumor treatment system, designed and realized combining Complex Programmable Logic Device and other electrical components, not only can on-line monitor the parameters of pulse rise time, fall time, repeat frequencies and pulse durations, et al, but also can close-loop control partial parameters fore mentioned. The paper detailedly introduces the primary principles of PWM controlling and the concretes method of frequency difference multiply, briefly illustrates the control strategy of Liquid Crystal Display module, real time clock module and the capacitor switching circuit, particularly discusses the scheme and the function of the voltage measurement module, the rise time and fall time measurement module, the voltage amplitude controlling module and the keyboard interface circuit, the RS-232 communication module. Moreover, the simulation processes and results of voltage amplitude measurement module and rise time/fall time measurement are recommended in this paper. The classic foreground and background pattern is chosen as the software organizing form in this paper, in which the main program is background application and the interrupt service program is background correspondingly. By switching the foreground and background program instantly, sorting priority of applications, the soft can respond a series task of measurement, controlment and display instantly.Including the adjustment and test to measurement module, controlment module and display module, the paper accomplishes the adjustment and test to the whole high voltage steep pulse tumor treatment system. The test results indicate that the design scheme and the realization method brought forward in this paper can satisfy the requirements of tumor cell irreversible mechanism research and clinic application, obtaining the anticipated target.更多还原