【作者】 朱晓瑜；

【导师】 王忠义； 高勃；

【作者基本信息】 第四军医大学 ， 临床口腔医学， 2005， 硕士

【摘要】 快速成形技术在医学领域应用主要是制作医学物理模型、个性化植入体、赝复体和组织工程人工器官的载体。其中通过快速成形技术制作组织工程人工器官载体是现在的研究热点也是今后的发展方向,在四种常用快速成形方法中SL法虽然应用广泛,但因其设备核心部件——激光器寿命短,加工材料种类单一、价格昂贵,无法参与组织工程人工器官载体的研发;相比较而言,SLS法最大的特点是可加工材料范围宽泛,具有很好的发展前景;但国内有关SLS法在医学领域应用的相关研究较少,本研究就SLS法在制作医学物理模型和制作修复人下颌骨缺损的个性化钛植入体支架方面作了初步的探索,为SLS法在医学领域的广泛应用奠定了基础。 本研究首先用螺旋CT扫描离体人下颌骨,得到断层图像数据不经任何转换直接输入MIMICS软件进行三维重建,得到CAD三维数模,输入Surfacer软件除去杂点干扰,平滑曲面后,保存为STL文件,输入SLS快速成形系统通过激光烧结精铸蜡粉所制作的人下颌骨复制体,其形态、大小及结构与下颌骨实体标本基本一致。然后建立的人下颌骨大面积缺损的CAD三维数字模型,在Surfacer软件中通过健侧数据的镜像翻转实现对缺损区个性化预制钛植入体支架的三维数字设计,输入SLS快速成形更多还原

【Abstract】 Rapid Prototyping Technology is used to make medical physical models, individual precast titanium frameworks, facial prosthesis and carrier of the Organ-Tissue Engineering. Studying how to construct the carrier by RP ways is a rising research field in this centrury, and SL is the most extensive-used way. But its laser aid has short working time. Kinds of the materials are also limited and their price is very high. By contrast with the SL , SLS cann’t only use many kinds of materials, but also can construct the carrier by some special materials. Domestic reports of the SLS in medical areas is a little. So to make physical model and individual precast titanium frameworks by SLS are to be discussed in the paper.Firstly in this paper human mandibula was scanned by spiral CT. Then the data from CT was import into software (MIMICS 7.10) to reconstruct 3-D digital model. Software (Surfacer 10.5) was used to remove useless points , smooth the curves and output the STL file. The file was input into the rapid prototyping system, and was converted to slice format. At last processing parameters were chosen, 3D stereo mandibula model was built by wax powder by Selective Laser Sintering layer by layer. Contrast to original mandibula, wax model was alike in shape, structure and size. Secondly 3-D digital model更多还原