【作者】 杜丽丽；

【导师】 李宝林；

【作者基本信息】 陕西师范大学 ， 有机化学， 2005， 硕士

【摘要】 手性化合物及其绝对构型的研究已经成为立体化学研究中最主要、最活跃的部分之一,所以确定分子中手性碳原子的绝对构型显得十分重要。自从上世纪70年代以来,国外即已开始在这一方面进行积极地探讨,并提出了诸如单晶X-射线衍射法、手性光学法和核磁共振法等经典方法,但这些方法都存在较大的局限性。近年来,国外提出了应用2-(9-蒽基)-2-甲氧基乙酸(9AMAA)及2-(9-蒽基)-2-羟基乙酸乙酯(9AHA)为手性识别试剂,通过核磁共振法确定手性碳原子绝对构型的方法,并取得了一些显著的成果。但是,在国内这一领域的研究未有文献报道。我们从此类化合物的合成、外消旋体的拆分、产物光学纯度的测定等方面进行研究,并取得了一些进展。本论文的主要内容包括: 1.对应用核磁共振(NMR)确定绝对构型的方法进行了综述,主要介绍了应用9AMAA、9AHA为手性识别试剂,通过NMR确定绝对构型的原理和方法。近年来,随着新的手性试剂的不断涌现和高场核磁共振技术的发展,核磁共振法在识别手性化合物绝对构型中成为最受关注的方法,其中9AMAA、9AHA试剂因被应用于NMR对手性碳原子绝对构型的测定而受到重视。因此,如何进行9AMAA、9AHA的合成、手性拆分并获得光学纯手性识别试剂的研究已成为我们实验的一个关键。本文也综述了外消旋体的拆分方法,并详述了毛细管电泳在手性分离方面的研究及应用进展。 2.对9AMAA、9AHA等四种化合物的合成研究进行了详细的论述,该实验中,基于Riguera等人的研究思路,由蒽经傅-克酰化、还原、水解反应可得到(±)-9AHA;外消旋体9AHA继续发生甲基化、水解、拆分反应后即可获得(R)-和(S)-9AMAA。我们的合成实验取得了较为理想的进展,已经能够得到9AHA和9AMAA等四种手性物质。我们优化了反应条件,得到了合成目标产物的较好方法。 3.我们对四种手性物质进行了手性分离。薄层色谱(TLC)是最简便的色谱技术之一,本文以键合有β-环糊精(β-CD)的硅胶为手性固定相,利用TLC法对四种手性物质进行了的拆分研究,通过对流动相的选择与优化达到了良好的拆分效果。化学拆分法是广泛使用的一种拆分方法,而且也是制备旋光纯化合物最重要和最更多还原

【Abstract】 Absolute configurations of chiral compounds have been one of the most important contents in stereochemistry. It is very significant to determine and illustrate spatial configurations of chiral compounds. Since 1970s, some foreign scientists have begun to study this problem and reported a great deal of progress in this field. Now there are some classic methods such as X-ray crystallography analysis, Chiroptical method and NMR method. However, all of these methods have their own limitations, respectively. One of the most important methods is to use 9AMAA and 9AHA as novel chiral auxiliary reagents, with NMR to elucidate absolute configurations. This innovation acts remarkably. However, most of Chinese scientists paid little attention to this field. We have been studying this problem for several years. And some research has been done in the field of synthesis and resolution of these novel chiral auxiliary reagents. Our researches and results are reported in the paper.1 .This paper reviews the NMR methods to determine the absolute stereochemistry of chiral compounds. Especially, it is addressed to recognize absolute configurations of chiral compounds by applying 9AMAA and 9AHA which are modified Mosher’s reagents. With the appearance of new chiral auxiliary reagents and development of upfield NMR technique, NMR method can be taken more advantages of. There are many advantages, which can make NMR method more useful. Finally 9AMAA and 9AHA were found to be novel in NMR method. Racemic resolution is the main route for preparation of optical pure chiral compounds. This article also reviews resolution methods of enantiomers. The application and development in the field of chiral separation by CE are reviewed particularly.2.In this chapter, the syntheses of 9AMAA and 9AHA were discussed in detail. Based on Riguera’s idea, we also chose anthrance as a reactant. (±)-9AHA could be obtained from anthrance by Friedel-Crafts acylation, reduction, hydrolysis, and (R)- and (S)-9AMAA could be obtained from 9AHA by methylation, hydrolysis, resolution. As a result, some important intermediates and racemes of 9AMAA and 9AHA were obtained in our experiments. Various reaction conditions were investigated and the optimum更多还原