【作者】 蔡三郎；

【导师】 黄海；

【作者基本信息】 福建中医学院 ， 中医临床基础， 2004， 硕士

【摘要】 目的：研究仲景和解行气法(小柴胡汤合半夏厚朴汤加百合的复方)治疗抑郁症。 方法：本研究采用随机分组的原则将80例病例分为中药研究组40例(小柴胡汤合半夏厚朴汤加百合的复方)与对照组口服百优解40例，治疗6周观察其结果。 结果：(1) 抑郁症患者经两组治疗前后Hamilton抑郁量表HAMD总分、减分率比较(x±s)治疗后与治疗前相比P＜0.01，两组间比较，均为P＞0.05，两组无显著性差异。(2) 经两组治疗前后CGI量表分比较(x±s)治疗后与治疗前相比P＜0.01，两组间比较P＞0.05，两组无显著性差异。(3) 经两组药物治疗疗效(％)治疗后与治疗前两组间比较P＞0.05，两组无显著性差异。(4) 两组治疗各周TESS量表分比较研究组与对照组相比P＜0.01，两组差异有显著性。(5) 小柴胡汤合半夏厚朴汤加百合的复方与百优解治疗后，其副作用的发生明显少于百优解(P＜0.01)，有显著性差异。结论：通过临床研究，我们认为，小柴胡汤合半夏厚朴汤加百合的复方是一种安全、有效的抗抑郁药，试验中未发现有任何的撤药现象，在常用剂量下不良反应极其轻微。更多还原

【Abstract】 Objective: To observe the clinical effect of the treating method of harmonizing Shaoyang and activatingQi, created by Zhangzhongjing, on depression. The applied prescription consisted of Minor Decoction of Bupleurum, Decoction of inelliae and amaagnoliae Officinalis and Bulbus Lilii.Methods: 80 cases of depression were divided randomly into treatment group(n=40) treated with Chinese herbs, and control group treated(n=40) with prozac. The therapeutic course lasted for 6 weeks.Results: (1) The HAMD value of both groups decreased significantly after treatment (P<0. 01=. After treatment, there was no obvious difference between two groups(P>0. 05) . (2) CGI value decreased obviously after treatment (P< 0.01). After treatment, there was no obvious difference between two groups(P>0. 05). (3) As to the curative effect, there was no significant difference between 2 groups (P>0. 05) . (4) As to the TESS value at continual weeks, there was obvious difference(P>0. 05). (5) The side effects of the treatment group were obviously less than those of the control group(P<0. 01).Conclusion: The clinical study shows that this prescription is safe and effective for anti-depress ion. No withdrawal phenomena occurred in the study, only minimal adverse reaction was observed under the routine dosage.更多还原