【作者】 张丽霞；

【导师】 周国英；

【作者基本信息】 福建中医学院 ， 中医内科学， 2004， 硕士

【摘要】 目的：寻求延缓糖尿病肾病肾功能恶化的中西医结合治疗的有效方法。 方法：将60例病例随机分为A组及B组。两组在年龄、性别、24小时尿蛋白定量和血肌酐经统计学处理，未见显著差异。经饮食、运动及降糖药物治疗，有效严格地控制血糖，空腹血糖＜7.0mmol／L者，糖基化血红蛋白＜8％的情况下。A组为洛汀新治疗对照组，B组为益气活血汤+洛汀新组。治疗时间2个月，检测治疗前后24小时尿蛋白定量、Scr及血尿素氮(BUN)水平，观察指标用均数±标准差((?)±s)表示，治疗前后用成对t检验及组间对照用t检验。 结果：洛汀新组、益气活血汤+洛汀新组治疗前后Scr水平均无显著差异(p＞0.05)。洛汀新、益气活血汤+洛汀新组治疗后见尿蛋白定量的下降，有统计学意义(p＜0.05)。两组间比较，益气活血汤+洛汀新组降低尿蛋白的疗效明显优于洛汀新(p＜0.05)。 结论：中西医治疗在延缓糖尿病肾病肾功能恶化，改善患者生活质量方面疗效优于单用ACEI。更多还原

【Abstract】 Objective:To explore the effective therapeutic method of combination of TCM and western medicine to postpone renal function deterioration of diabetic nephropathy.Method:According to WHO diagnosis criteria and TCM differentiation criteria, we selected 60 cases (29 male and 31 female), Which were divided into two groups (A and B) at random.Two groups have no significant difference by statistics in age,sex,urine protein/24h and serum creatinine.With control die,sport and have hypoglycemic drug or subcutaneous injection insulin therapy to control blood glucose strictly , fasting plasms glucose(FPG) < 7.0mmol/L,glycosylated hemoglobin <8%,A group was treated by Lotensin ( 10mg-20mg. Qd ) for 2 months,B groups was treated by both yiqihuoxue decoction and Lotensin for 2 months,detected urine protein /24h, serum creatinine(SCR) and blood uria nitrogen(BUN),observing marker indicated by mean and standard deviation before and after theraphy,contrasted by pairedsample T-Test or independent sample T-Test between before and after theraphy for two groups.Result: Scr and BUN of A group had no significant difference than those of B group (p>0.05 ) . urine protein/24h of two groups descented after theraphy , which has signficance difference in statistics . B group is prior to A group.Conclusion: It’s better to treat with combination of TCM and western medicine than only ACEI in postponing renal function deterioration of diabeticnephropathy and progressing life quantity.更多还原