【作者】 赵春辉；

【导师】 王兆禹； 杨秋萍；

【作者基本信息】 昆明医学院 ， 内科学， 2004， 硕士

【摘要】 目的：探讨高血压病患者左房重构性变化、影响因素及其程度，及其与左室结构功能变化的关系。 方法：以切面及多普勒超声法检测89例轻中度高血压病患者左房大小及左室结构和功能指标。通过多元逐步回归分析，甄选影响左房大小的独立影响因素，并以协方差分析校正其他因素的混杂影响后，比较不同左室构型组左房内径差异，正常血压者82例为对照。 结果和结论：左房内径与收缩压水平、左室壁厚度或肌重量、以及左室舒张功能指标间存在显著性多元复相关和直线相关关系：血压，主要是收缩压水平越高，左室壁越厚，左室舒张功能损害越甚，左房就越大。此外，影响高血压病左房构形的其他因素尚有超重或肥胖程度、心率等，在评估高血压病左房构形变化时应予关注。更多还原

【Abstract】 Objects: To investigate the remodeling changes of left atrium, correlative factors and the relationship between changes of left atrial size and changes of left ventricular structure and function in essential hypertensive patients.Methods: The dimension of left atrium and indices of left ventricular structure, systolic and diastolic functions were measured by Two-dimensional and Doppler echocardiography in 89 mild to moderate hypertensive patients.The independent factors effecting on the dimension of left atrium were identified by method of multivariance stepwise regression analysis. After adjusting for the confounding effects of other variables by covariance analysis, the differences of the dimension of left atrium among the different left ventricular remodeling pattern groups were compared with 82 normotensive subjects as a control.Results and Conclusion: The results of multivariance analysis showed that there was a statistically significant multiple and linear correlation between the dimension of left atrium and systolic blood pressure, thickness of left ventricular wall or left ventricular mass, and indices of left ventricular diastolic functions. If the systolic blood pressure level is higher, the left ventricular wall is thicker, and the left ventricular diastolic function is worse, the dimension of left atrium would be larger. Moreover the overweight or obesity, heart rate were found to be the affecting factors on size of left atrium as well and would be considered in those studies on left atrial structure in essential hypertensive patients.更多还原