载药微粒的制备及性能研究

【作者】 纪桂华；

【导师】 宋洪昌；

【作者基本信息】 南京理工大学 ， 材料学， 2004， 硕士

【摘要】 为掩盖布洛芬的不良气味和改善其溶解性及减弱其对胃肠道的刺激性，本论文以布洛芬为核，分别以壳聚糖、壳聚糖和海藻酸钠、丙烯酸树脂为壳制备了三种核-壳结构的复合粒子。并采用红外光谱、紫外-可见光谱、激光粒度仪、扫描电镜、差示热分析仪等分别对三种复合粒子进行结构和性能表征。结果表明：用复乳法制备的布洛芬-壳聚糖微球表面比较粗糙，粒径小；用复凝聚法得到的布洛芬-海藻酸钠-壳聚糖微囊缓释性最佳；而用液中干燥法制备的布洛芬-丙烯酸树脂微球微球表面比较光滑，制备工艺比较简单。本文还对三种微球缓释效果的不同原因进行了分析。更多还原

【Abstract】 In order to mask bad odor of ibuprofen, improve its dissolvability and weaken its pungency to gastrointestinal tract, three kinds of core-shell microspheres were prepared . Ibuprofen was used as core and chistosan, chistosan-sodium aiginate and Eudragit E were used as shell respectively. IR, VIS-UV, Particle size analysis, SEM and DTA were used to analyse their structures and characters. Results showed that the surface of ibuprofen-chistosan microphere obtained by multiple emulsion method was coarse and its size was small; the releasing performance of Ibuprofen-chistosan-sodium aiginate micropheres obtained by multiple emulsion method was the best; the surface of Ibuprofen-Eudragit E obtained by method of intra-liquid was rather smooth and its preparation technic was simple. The reasons with different release effects were also discussed.更多还原