3-甲基-4-丁酰氨基-5-氨基苯甲酸甲酯的合成

【作者】 吴佳；

【导师】 蔡春；

【作者基本信息】 南京理工大学 ， 应用化学， 2004， 硕士

【摘要】 以3-甲基-4-丁酰氨基苯甲酸甲酯为原料，经硝硫混酸硝化、铁粉还原，得到新型药物中间体3-甲基-4-丁酰氨基-5-氨基苯甲酸甲酯。并对硝化反应中的底酸用量、混酸配比、反应温度、反应时间、后处理等因素进行了研究；同时也对还原反应中的电解质选用、反应温度、反应时间、铁粉用量等方面进行了研究。初步确定了合成3-甲基-4-丁酰氨基-5-氨基苯甲酸甲酯可应用于工业化生产的工艺条件。更多还原

【Abstract】 The starting material Methyl 4-butylamino-3-methylbenzoate was nitrated with mixing acid of sulfuric acid and nitric acid, then reduction in the presence of Fe powder to afford methyl 4-butylamino-3-methyl-5-aminobenzoate, which is a new pharmaceutical intermediate. Several factors in nitration were investigated, including the amount of substrate acid, the ratio of mixing acid, temperature, time and the final dealing methods. Meanwhile, factors in the reduction including the choice of electrolytes, temperature, time and the amount of Fe powder were studied. The conditions of the synthesis of methyl 4-butylamino-3-methyl-5-aminobenzoate were preliminarily determined, which is also applicable in industrialization.更多还原