【作者】 郅扶旻；

【导师】 龚占悦；

【作者基本信息】 黑龙江中医药大学 ， 中医内科学， 2004， 硕士

【摘要】 慢性萎缩性胃炎(CAG)是消化系统的常见病、疑难病，属中医胃脘痛、痞满等范畴。病理上以胃粘膜变薄，固有腺体萎缩或伴有肠上皮化生(IM)、不典型增生(ATP)为其特点，每年癌变率约百分之一。1978年世界卫生组织将其列为癌前状态之一，引起国内外医学界的高度重视。现代医学对CAG病因尚未阐明，故很难制定出一个成熟的治疗方案。而近年来中医治疗CAG已显示出其优势和广阔的前景。 导师龚占悦教授以健脾益气、活血化瘀法为治疗原则，应用益胃消增胶囊治疗CAG，在临床上取得了良好的效果。为进一步探讨益胃消增胶囊治疗CAG的作用机理，我们进行了动物实验研究。 本实验采用综合造模法制作CAG模型大鼠，观察各组大鼠一般状况、胃液Ph值、胃蛋白酶活性、胃泌素(Gas)及病理等指标的变化。结果证实了益胃消增胶囊在治疗CAG时能使胃液Ph值下降、胃蛋白酶活性升高(P＜0.01)，有刺激Gas分泌的作用。并且能明显消除胃粘膜炎症，改善甚至逆转CAG大鼠的胃粘膜萎缩、肠上皮化生及不典型增生等病理学改变。为临床应用益胃消增胶囊治疗CAG提供了理论依据，也为CAG的患者提供了有效的治疗方药。更多还原

【Abstract】 CAG is a common digestive systematic disease that gastritis becomes thinner, appropriate organization atrophied, or having the change of bowel, unmethodical growing are its’ flavor. In 1978 WHO has defined it as one of the precancerous lesions. Because its’ malady complex, there isn’t an effctive therapeutic method. But in recent years the TCM has shown its advantages.Professor GongZhanYue uses YiWeiXiaoZeng capsule to remedy CAG and have good remedy results. In order to probe into the therapeutics mechanism of the prescription, we have carried out animal experiment.We tried to observe the changes of the CAG model rats’ ordinary condition, gastric juice PH levels, pepsin activity, GAS levels, SS levels and pathological change. The result shows: YiWeiXiaoZeng capsule could increase GAS levels, decrease gastric juice PH levels, improve the pepsin activity(p<0.01). It improve the CAG model rats’ gastritis atrophic, IM, ATP and inflammation obviously. It also provide the theoretical base and effective therapeutic method for the treatment of CAG .更多还原