【作者】 宋歌；

【导师】 孙伟正；

【作者基本信息】 黑龙江中医药大学 ， 中医内科学， 2004， 硕士

【摘要】 本文在综述了近年来国内外中医和西医对原发性血小板减少性紫癜(Idiopathic thrombocytopenic purpura，ITP)的治疗和研究进展后，对导师自拟的治疗慢性原发性血小板减少性紫癜(Chronic idiopathic thrombocytopenic purpura，)的有效方药“血思饮胶囊”的疗效及相应指标进行临床研究。本研究通过对40例CITP患者治疗前后的血小板计数、血清PAIgG含量、骨髓巨核细胞数量的观察，比较血思饮胶囊与强的松的疗效。结果发现血思饮胶囊能减轻患者出血等症状，有效地提升患者的血小板计数(P＜0.01)，明显降低血清PAIgG含量(P＜0.01)，降低骨髓巨核细胞总数、原巨加幼巨和颗粒巨数量(P＜0.01)，而提高产板巨数量(P＜0.01)。但血思饮胶囊治疗CITP总有效率与强的松相比疗效相当(P＞0.05)。 本研究还发现血思饮胶囊对CITP各型患者均有明显效果(P＜0.01)，尤其对气虚不摄型的疗效最好，其血小板计数提升优于另两型(P＜0.05)。更多还原

【Abstract】 After concluded some research of traditional Chinese medicine and western medicine into the subject of Idiopathic thrombocytopenic purpura (ITP) in resent years, we study the effect and some parameters of Xuesiyin capsule which is used to treat Chronic idiopathic thrombocytopenic purpura (CITP) .We research 40 subjects of CITP with their platelet count, blood PAIgG level, amount of megakaryocyte, and compared with those cured by Prednisone. From the treatment we find Xuesiyin can increase the platelet count of CITP rapidly ( P<0.01 ) , effectively decrease the PAIgG level in the blood of CITP (P<0.01) , striking decrease the megakaryocyte and unripe megakaryocyte in CITP bone marrow(P<0.01) , but megakaryocyte with producting platelet striking increased (P <0.01) .The total effective rate of Xuesiyin on CITP approximates to Prednisone’s (P>0.05) .From the treatment group, we also find the response of Xuesiyin is remarkable to all sorts of CITP (P<0.01) , especially to spleen failing to control blood, which platelet count is much higher than the other two groups (P<0.05) .更多还原