【作者】 常青；

【导师】 何耀；

【作者基本信息】 中国人民解放军军医进修学院 ， 老年流行病学， 2004， 硕士

【摘要】 目的：初步探讨职业电磁辐射暴露及其他危险因素与老年人认知功能障碍的关系 方法：选取总参通讯部北京第一干休所军队离退休老干部为研究对象，设计调查问卷，由经过培训的调查员进行面对面问卷调查，化验检查按统一要求和操作程序进行，在解放军总医院生化科完成。所有数据录入Access数据库，并导入SPSS12.0版统计软件进行分析。根据简易精神状态检查量表得分将研究对象分为认知功能异常组和正常组进行比较，单因素分析计算OR值(95％可信限)和t值；多因素分析采用非条件Logistic逐步回归模型。 结果： 1．社会人口学情况：本研究实际调查273人(男229，女44)，平均68.8±5.8岁，其中已婚者254人(占总体的93.0％)，脑力劳动者占大多数(97.1％)。 2．单因素分析结果显示吸烟、脑卒中病史和慢性阻塞性肺病病史在两组间差异明显，其OR值(95％可信限)分别为2.61(1.16-5.88)、5.09(2.05-12.68)和2.74(1.15-6.54)。 3．多因素分析结果显示调整了年龄、性别及其他影响因素后，吸烟、饮酒、收缩压水平增高、胆固醇水平增高和脑卒中病史是认知功能损伤的危险因素，OR值(95％可信限)分别为3.87(1.40-10.68)、4.07(1.12-14.79)、1.04(1.01-1.07)、2.04(1.11-3.74)、4.79(1.56-14.68)；电磁暴露的OR值(95％可信限)为0.60(0.24-1.51)。 结论：吸烟、饮酒、脑卒中病史、血压升高和高胆固醇血症是促使认知功能减退的危险因素，未能发现电磁暴露与认知功能改变的关系。更多还原

【Abstract】 Objective: To investigate magnetic-field exposure and other risk factors associated with cognitive function in military aged people.Methods: A cross section study in 273 military retired cadres were carried out. All of the subjects filled in the standard questionnaires, and the levels of serum FBG, TC, TG, HDL, LDL were determined. By cognitive impairment group, Uni variate and multivariate analyses were conducted using Logistic regression model.Results: Univariate analysis showed smoking, the history of stroke and COPD were significantly different between normal and abnormal cognitive function groups, and the OR(95%CI) were 2.61 (1.16-5.88), 5.09 (2.05-12.68) and 2.74 (1.15-6.54) , respectively. After adjusted for age, gender and other factors, smoking, drinking, history of stroke and higher SBP and TC level were danger to cognitive function impairment, and the OR(95%CI) were 3.87 (1.40-10.68) , 4.07 (1.12-14.79) , 4.79 (1.56-14.68) , 1.04 (1.01-1.07) and 2.04 (1.11-3.74) , respectively. There was not significant relationship between magnetic-field exposure and cognitive function impairment, and the OR(95%CI) was 0.60 (0.24-1.51) .Conclusions: Smoking, drinking , high blood pressure and TC level may he the risk factors of cognitive function impairment.更多还原