【作者】 孙伟；

【导师】 艾红军；

【作者基本信息】 中国医科大学 ， 口腔临床医学， 2004， 硕士

【摘要】 目的：采用Meta-分析法研究羟基磷灰石(Hydroxyapatite，HA)涂层种植体的临床应用现状，评估了HA涂层种植体修复的总体平均成功率。材料和方法：采用计算机检索1990～2002年国内所有口腔类杂志有关涂层种植体修复的文献。根据纳入和排除标准，分两步选择适用的文献共计14篇。并对选用的文献进行了质量评价。对种植体成功标准作了统一的定义，作为统一的研究结果，对文献进行了均衡性检验，然后把相关文献数据合并计算出HA涂层种植体修复的总体平均成功率。结果：所有文献按0-1标准的平均加权质量分为0.61+0.06，各篇文献的质量分分别作为其合并样本量的权数。观察一段时间后计算临床成功率的文献11篇，观察时间在2年以下，2～4年和4年以上所得总体临床成功率的均值分别为98.16％，94.73％，92.02％，通过寿命表法来获得累积成功率的3篇文献中，随访1年，2年，3年的总体平均累积成功率分别为95.1％，92.51％，91.05％，由于10号文献的随访时间只有3年，故而此3篇文献3年后的累积成功率无法合并。结论：HA涂层对骨内种植体的临床成功率是有影响的，HA涂层种植体修复近期的临床成功率及累积成功率较高，而其远期成功率由于观察时间相对较短，尚需进一步的临床观察研究。更多还原

【Abstract】 Objective: Our aim was to study the clinical application of hydroxyapatite -coated implant by using a Meta-analysis review procedure .Methods: Using a systematic computer search for the Chinese literature from the dental journals in China from 1990 to 2002, papers were selected using an in-and-exclusion protocol in a two-step procedure. In addition, the 14 papers selected were subjected to a quality assessment. All studies used an identical definition of success standard of hydroxyapatite-coated implant. After a homogeneity test, the mean overall survival rates were calculated by pooling the data from the studies. Results: On a 0-1 scale, the weighed overall mean quality score of the studies was 0.61 (s.d.0.06), the quality score was used as weight for pooling the samples f studies. There are eleven studies reported implant survival using overall percentage, the overall mean survival rates for 2 years below, between 2 to 4 years, 4 years above are 98.16%, 94.73%, 92.02%, respectively. The rest three studies reported implant survival using life-table analysis, the mean cumulative survival rates for 1 year,2 years, 3years are 95.1 %, 92.51 %, 91.05 %, respectively. Because the follow-up time of one study was only three years, their cumulative survival rates after 3 years could not be pooled. Conclusion: HA coatings have an effect on survival rates on endosteal imlant, the recent survival rates of HA-coated implant restorations are high, However, because of the follow-up time is short, the long-term survival rates need for further research.更多还原