【作者】 周文献；

【导师】 胡晓桦；

【作者基本信息】 广西医科大学 ， 肿瘤学， 2004， 硕士

【摘要】 目的：研究Bcl-2、Bax和GST-π在非霍奇金淋巴瘤(NHL)中的表达及其对化疗效果的影响。方法：收集59例非霍奇金淋巴瘤患者的临床资料及淋巴结活检组织蜡块。采用免疫组化S-P法检测蜡块标本中Bcl-2、Bax和GST-π的表达，应用相应的统计学方法分析各项检测指标与临床病理分型之间的相互关系，以及与临床化疗疗效之间的关系。结果：1）Bcl-2在B细胞性NHL中的表达强度和表达率均高于T细胞性NHL(P < 0.01)。2）在B和T细胞性NHL之间Bax和GST-π的表达无显著性差异(P>.05)。3）Bcl-2在低度恶性NHL中的表达要显著高于中高度恶性NHL( P < 0.05)。4）Bax在低度恶性NHL和中高度恶性NHL中的表达无显著性差异( P > 0.05)。5）在中高度恶性NHL组，GST-π表达显著高于低度恶性组( P < 0.05)。6）Bcl-2表达阳性的中高度恶性NHL其完全缓解率要显著低于Bcl-2阴性表达组。7）GST-π表达阳性的中高度恶性NHL患者，其完全缓解率显著低于GST-π阴性表达组。8）Bcl-2、GST-π双阳性患者其治疗完全缓解率显著低于Bcl-2、GST-π双阴性患者(P <0.01)。结论：Bcl-2在B淋巴细胞性NHL中高表达，GST-π则在中高度恶性NHL中高表达，Bax在不同的细胞类型和恶性程度NHL间表达无差异；Bcl-2和GST-π表达组化疗CR率低，以Bcl-2和GST-π双阳性组CR率最低，提示二者可以作为化疗疗效不佳的指标。更多还原

【Abstract】 Objective: 　To study the expression and sign ifcance of Bcl-2、Bax and GST-πin non-Hodgk inps lymphom a (NHL ). Methods: 　Fifty night cases of NHL were examined with immunohistochemist ry technique. Results: 1) The expression of Bcl-2 in B-cell lymphoma was significantly higher than that in T-cell lymphoma(P<0.01). 2) Obvious difference of Bax and GST-πexpression in B-cell lymphoma and T-cell lymphoma was not observed (P>0.05) . 3) The expression of Bcl-2 in low malignancy group was significantly higher than that in intermediate and high malignancy group (P<0.01). 4) There was not significant difference of Bax expression in low malignancy group and intermediate and high malignancy group (P<0.01). 5)The expression of GST-π in intermediate and high malignancy group was significantly higher than that in low malignancy group (P<0.01). 6)Complete Remission rate in cases without Bcl-2 expression was higher than that with Bcl-2 expression in intermediate and high malignancy group. 7)Complete Remission rate in cases with GST-πexpression was lower than that without GST-πexpression in intermediate and high malignancy group. 8) Complete Remission rate in cases with GST-πand Bcl-2 expression was lower than that without GST-π and Bcl-2 expression in intermediate and high malignancy group Conclusions: Poor chemotherapy response was seen in cases with Bcl-2 and GST-πexpression in intermediate and high malignancy group NHL, Bcl-2 and GST-πwere able to be used as predictor of prognosis.更多还原