【作者】 姚海锋；

【导师】 李光；

【作者基本信息】 浙江大学 ， 生物医学工程， 2004， 硕士

【摘要】 临床上的许多疾病的过程往往伴随着人体感觉功能的变化，引起感觉迟钝或过敏。目前对人体感觉系统的检查多停留于定性的检查，不能满足医生深入了解感觉变化过程的需要。从上世纪70年代后期发展起来的定量感觉测量方法能够帮助医生定量的跟踪人体感觉的阈值的变化。我们研究的定量电流感觉测量方法就是一种定量感觉测量的新技术。 本文首先讨论了感觉神经功能评价的意义和当前神经系统检查手段的现状，回顾了定量感觉测量技术的发展和应用。然后详细论述了定量电流感觉测量系统的理论基础，包括三个方面：生理学基础；阈值检出算法(UDTR和Forced Choice方法)的理论基础；实验基础，即大量实验表明，5Hz，250Hz和2000Hz的正弦交流电流刺激分别可以代替加热，致冷和振动信号。 系统的设计部分是本文的重点。本系统有两种工作模式：下位机独立工作和通过RS232由上位机主控系统运行。下位机系统采用电池加DC／DC转换供电，CPU采用德州仪器的DSP，TMS320LF2407。下位机独立工作时，由DSP控制所有的接口和算法执行；模拟部分负责完成恒幅正弦电流输出的驱动和信号的反馈。系统采用软件硬件双重保护。 我们对系统进行了性能测试和初步的临床实验。结果表明，该系统能够稳定可靠的工作；在控制实验中得到的阈值数据有很好的可重复性。 最后，探讨了定量电流感觉测量方法的进一步研究和第二代系统需要改进的地方。更多还原

【Abstract】 Lots of diseases come with dysfunctions to the sensory system, causing hypoesthesia or hyperesthesia. But most of the examinations for sensory system are not quantitative. By 1970th a novel method named Quantitative Sensory Testing makes it possible for doctors to trace the changes of the sensory threshold of patients. The Current Perception Threshold system we developed is one of these kinds of methods.First, the significance to evaluate the sensory function and the current methods are discussed. The development and application history of Quantitative Sensory Testing technology is also reviewed. Then, Current Perception Threshold system is discussed in details including three main aspects: physiological background, theory of UDTR and Forced Choice method and experiment basis providing the evidence for us to substitute heating, cooling and vibration signals with 5Hz, 250Hz, 2000Hz sine current signals, respectively.The most important part of this thesis is the design of the system. The CPT system has two work modes: the embedded system runs independently and system runs controlled by PC. The embedded system is powered up with a battery and DC/DC converters. And the CPU is TMS320LF2407. When the embedded system works independently, the DSP controls the interface and performances the algorithms while the analog part implements V/I converting, constant current output and feedback stage. The system has both software and hardware protections.Performance testing of the system and the clinical experiments are carried out. It shows in the result that the system works stably. The experiment results are almost repeatable under the same conditions.At last, future research of the method and system improvement is discussed.更多还原