【作者】 赵淑娟；

【导师】 莫卫民；

【作者基本信息】 浙江工业大学 ， 农药学， 2004， 硕士

【摘要】 本文进行了含氮六元杂环类化合物2-氯-4-取代基烟酸及其衍生物、2,4,6-三取代嘧啶及其衍生物的合成研究。 第一部分介绍了2-氯-4-取代基烟酸及其中间体的合成研究，得到了一条合成2-氯-4-取代基烟酸的新的合成路线。以酮和氰基乙酸乙酯为起始原料经过醇醛缩合、消去、环合、水解等五步反应，得到了2-氯-4-甲基烟酸、2-氯-4-甲基烟酰胺、2-氯-4-乙基烟酸和2-氯-4-丙基烟酸。该路线采用的原料成本低、反应收率高。以氰基乙酸乙酯计，反应收率为35％。产品经HPLC分析其含量大于95％，结构通过红外光谱、质谱等进行表征。 第二部分介绍了2,4,6-三取代基嘧啶及其衍生物的合成研究。以β-二酮类化合物为起始原料分别与脒、脲、胍反应，得到了一系列2,4,6-三取代基嘧啶，并以之为原料进行衍生化反应，共合成了22个嘧啶类化合物。产品并经HPLC分析其含量大于95％，结构通过红外光谱、质谱等进行表征。更多还原

【Abstract】 This paper study mostly the synthesis of nitrous heterocyclic compound 2-chlorin-4-substitute-niacin and its intermediates ,2,4,6-three substitute pyrimidine and its intermediates.The first part study mainly the synthesis of 2-chlorin-4-substitute-niacin and its intermediates, we have designed our own way in which 2-chlorin-4-substitute-niacin is synthesized from ketone and cyanogens ethyl acetate, by retractation, expurgation, cyclization, hydrolytic decomposition, gain 2-chlorin-4-methyl-niacin, 2-chlorin-4-ethyl-niacin and 2-chlorin-4-propyl-niacin. The method has advantages of low material cost , easy to gain and high yield, its yield is 35%. Target product content is 95% by HPLC. The structure of 2-chlorin-4-substitute-niacin and its intermediates are characterized by IR and MS.The second part study mainly the synthesis of 2,4,6-three substitute pyrimidine and its intermediates, designed method in which 2,4,6-three substitute pyrimidine is synthesized from amidine. carbamide, uramine and two carbonyl compound, by this reaction we gain a series of 2,4,6-three substitute pyrimidine.We gain tweney-two compound in all. Target product content is 95% by HPLC. The structure of 2,4,6-three substitute pyrimidine and its derivative are characterized by IR and MS.更多还原