【作者】 陈松云；

【导师】 程丑夫；

【作者基本信息】 湖南中医学院 ， 中医内科学， 2002， 硕士

【摘要】 目的：观察舒冠滴丸治疗冠心病不稳定心绞痛阳虚痰瘀证的临床疗效，及其对血脂、心功能、C－反应蛋白的影响，初步探讨其临床作用机制。方法：采用随机对照双盲法设计，将60例确诊为不稳定心绞痛阳虚痰瘀证的患者随机分为治疗组和对照组，每组各30例。治疗组口服舒冠滴丸（10粒，每天三次），对照组口服复方丹参滴丸（10粒，每天三次），疗程均为4周。根据治疗前后心绞痛及其主要症状积分，心电图变化和硝酸甘油停减情况，以及血脂、C－反应蛋白、心功能评定疗效。结果：两组速效止痛作用、心电图变化均有明显改变，治疗组与对照组组间差异无显著意义（P>0.05）。临床症状积分的变化（P<0.01），长效止痛作用，第4周硝酸甘油减少量（P<0.01），C－反应蛋白（P<0.01），血清胆固醇（P<0.01）的变化，左室排出量和左室射血分数（P<0.01）的改善均优于对照组，而每搏量的改善不如对照组（P＜0.05）。两组均未发现明显毒副反应。结论：舒冠滴丸和复方丹参滴丸均有良好的速效止痛作用和改善心电图作用，在观察疗程内相对安全。而对临床症状积分的改善、长效止痛作用、第4周硝酸甘油停减率，血胆固醇、左心室收缩功能（CO、EF）、C－反应蛋白的作用以舒冠滴丸为优。舒冠滴丸对不稳定心绞痛阳虚痰瘀证疗效确切，更适合于该证的长期治疗更多还原

【Abstract】 Objective: TO observe the clinical effect of Shuguan Droplet pills（舒冠滴丸，SGDP）on the patients with the weakness of Yang with stagnation of the blood and retention of phlegm（阳虚痰瘀证，WYSR）in treating chronic unstable angina (UA)of Coronary heart disease(CHD)and to explore the clinical mechanism by the blood lipid, left ventricular systolic function and c-responsive protein (CRP).Methods: 60 cases with WYSR of UA were randomly, double-blindly divided into convention and treatment group. Each group had 30 cases. The treatment group was treated with oral SGDP(10pills,three times daily),while the convention group done with oral composite Dansen Droplet pills(CDDP,10pills,three times daily)during 4 weeks. The variation of angina pectoris symptoms, ECG, dosage of Nitroglycerin, blood lipid, left ventricular systolic function and CRP were observed before and after therapy.Results: The transient eradicate ache function, the change of　ECG of patients has been changed significantly in both group, but there was no difference each other (p>0.05).While 4 weeks later, SGDP not only appeared to be more effective than CDDP in improving symptoms(p<0.01),long-term eradicate ache function (p<0.01),but also seems to be superior to CDDP in decreasing the dosage of Nitroglycerin after 4 weeks (p<0.01),the blood level of TC and CRP (P<0.01).The level of SV，CO and EF of left ventricular had increased correspondingly (p<0.01).SGDP seems to be superior to CDDP in CO and EF (P<0.01) but inferior to CDDP in SV(P<0.05). Both group had no toxic and side function significantly.Conclusion: SGDP is a more effective drug in treating WYSR of chronic UA.更多还原