【作者】 丁玉青；

【导师】 尤昭玲；

【作者基本信息】 湖南中医学院 ， 中医妇科学， 2003， 硕士

【摘要】 育龄妇女放置宫内节育器（IUD）是临床上最常用的避孕方法，但置IUD后可致月经量多，经期延长等出血副反应，即“宫环出血”[1]。为探讨滋阴化瘀法对本病的作用机制，本研究建立了置铜宫内节育器（Cu-IUD）家兔模型，观察以滋阴化瘀法立法的宁环片对置Cu-IUD家兔子宫局部生化物质及血液流变学的影响，结果显示：1．滋阴化瘀法能降低前列环素（PGI2）含量，升高血栓素A2（TXA2），调整PGI2/TXA2比值。2．滋阴化瘀法能降低纤溶酶原激活物（tPA）的含量。3．滋阴化瘀法能降低一氧化氮（NO）、一氧化氮合酶（NOS）的活性。4．滋阴化瘀法能降低红细胞比容，全血比粘度和血浆比粘度，改善血液流变性。上述实验结果表明：滋阴化瘀法能调整子宫局部生化物质的释放，改善血液流变性，对置宫内节育器后子宫异常出血具有良好的防治作用。更多还原

【Abstract】 IUD is the most widely used intrauterine device method for women of child bearing age. But it can cause side reactions such as hyper-menorrhea and menostaxis, etc. To study the mechanism of the therapy of supplementing Yin and removing blood, We made a Cu-IUD-wearing Rabbit given Ning huan pian which is based on supplementing Yin and removing blood stasis (SYRB) through several aspects including as prostacychine, thromborane A2, plaminogen activator and blood rheology. These were the results.1. SYRB decreased the contents of prostacycline (PGI2), and raised thromorance A2 and the ratio of PGI2 to TXA2.2. SYRB method decreased the contents of tissue plasminogen<WP=5>activator (t-PA).3. SYRB decreased the activity of No and NOS.4.SYRB decreased the demsity of hematocnit, total blood viscosity (low, middle, high) and seram viscosity, and improved blood rheology.All mentioned above indicate that SYRB method can regulate the release of biochemical medium in the uterine tissues and improve blood rheology, So endometrorrhagia caused by IUD- wearing can be prevented and cured effectively.更多还原