参芪复方降血糖机理研究

【作者】 罗杰；

【导师】 谢春光；

【作者基本信息】 成都中医药大学 ， 中医内科学， 2003， 硕士

【摘要】 目的：通过大鼠糖尿病模型的建立，研究参芪复方对血糖调节激素的影响及改善代谢紊乱的作用及机制。方法：采用Alloxan腹腔注射诱导糖尿病大鼠模型，并随机分为参芪复方大、中、小剂量组，西药组，模型组及正常对照组。治疗三周后，通过放射免疫、血清酶学检查等方法，测定各组大鼠空腹及餐后2小时BG，INS、GLU、GLP-1、C-P，SOD并做胰腺组织病理切片观察。结果：糖尿病大鼠存在着上述指标的明显异常。参芪复方可改善糖尿病大鼠高血糖代谢紊乱状态，提高血清胰岛素含量，降低拮抗激素水平，促进胰岛β细胞的增殖和修复，综合疗效优于西药对照组。结论：参芪复方可在多个环节、多个水平，发挥降血糖作用。更多还原

【Abstract】 Objective:To investigate the action and mechanism of Shenqi Polypharmaceutical on how to influence diabetic rat’s blood glucose regulating hormones and improve its supersession disorder state. Methods-.Established DM rats by intraperitoneal injection of Alloxan are to be diveid randomly in five groups:model control,DM model treated with low dowsage middle dowsage and high dosage of SQ and , BS group respectively.Normal control group is also set.After three week’s treatment, detecting rat’s following materials including BG, INS GLIK GLP-K C-P, SOD both in am empty stomach state and postprandial state with the use of radioimmuno assay and serum enzyme examination ,meanwhile rat’s pancreatic tissues are also made into pathological section for analysis. ResuItrDM rats do exist abnormality of the above mentioned materials.SQ can improve the DM rat’s high blood glucose metabolism disorder ,raising INS content in serum whereas taking down the GLU level ;accelerating the renovation and proliferation of the pancreatic B cells.The general curative effect of SQ is better than the west medicine corss-refer group. Conclusion:SQ can act in multiple ways and levels to degrade blood glucose.更多还原