【作者】 李云平；

【导师】 张庚扬；

【作者基本信息】 天津中医学院 ， 中医外科学， 2003， 硕士

【摘要】 目的 以中医辨证论治的思想为指导，采用中药制剂“消疽1号”治疗糖尿病足坏疽，以山莨菪碱作对照，探讨中药对糖尿病足坏疽（气阴两虚型）微循环障碍的改善作用。同时初步阐述其作用机制。方法 本研究将受试对象分为两组。治疗组24例，以消疽1号口服治疗；对照组24例，山莨菪碱静脉滴注。1个月为1个疗程。于治疗前和1个疗程后分别做血液流变学、甲皱微循环、足背血流变化和踝肱指数检测，将中药改善糖尿病足坏疽（气阴两虚型）微循环变化与对照组治疗的疗效相比较。结果 治疗组愈显率87.50%，总有效率95.83%，对照组愈显率45.83%，总有效率91.67%。两组疗效比较有显著性差异，“消疽1号”（治疗组）组疗效优于山莨菪碱（对照组）组。结论 益气养阴、和营解毒的代表方剂“消疽1号”，通过对微循环障碍的改善调节作用对于气阴两虚型糖尿病足坏疽具有良好的临床疗效，其效果肯定，且无毒副作用，为临床上中医药治疗糖尿病足坏疽提供了新的治疗方案更多还原

【Abstract】 Objective: To discuss the effect of diabetic foot gangrene belong to qi and yin deficience type treated by“xiaojuⅠ” based on the theory of TCM compared with 654-2 and study its mechanism on the disorder of microcirculation.Methods: Patients with diabetic foot gangrene lesions were randomly divided into two groups: treatment group and control group, each group containing 24 cases. One month was a course of treatment. Under the same basic treatment, the treatment group was treated with Chinese Materia Medicine , while the control group with the rest 24 cases was treated with anisodamine(654-2). The methods had been applied to the two groups differently for a course of treatment. We observed the changes of blood rheology and nail fold microcirculation and etc in 48 patients with diabetic foot gangrene lesions before and after treatment, who had been treated by reducing blood sugar and resisting infection. Results：Clinical observation on 48 cases showed good results: the total effects were 95.83%and 91.67% in treatment group and control group respectively. And there was an obvious difference between them (p<0.05). In the treatment group, 12 cases were cured, 9 cases showed improved and 1 case ineffective with the total effective rate of 87.50%. For the control group, 6 case were cured, 5 cases showed improved and 2 cases ineffective, the total effective rate being 45.83%. The results indicated that the blood rheology had been significantly improved and the disorder of microcirculation had been relieved markedly after treatment in both groups. But difference between treatment group and control group were obvious, the comparison proved the curative effect in the treatment group was better than the control group(P<0.05). So we can draw a conclusion that In the treatment group the therapeutic result was better than that of control group. Conclusion：“Xiao Ju 1" is functional for the treatment of diabetic foot gangrene and also for the improvement of the disorder of microcirculation ,witch provides an effective and safe method to treat diabetic foot gangrene with fewer side effects更多还原