【作者】 董梅；

【导师】 张守发；

【作者基本信息】 延边大学 ， 预防兽医学， 2003， 硕士

【摘要】 本文对猪附红细胞体病的血液学指标和病理学变化进行了探讨。试验中选用20头自然感染附红细胞体仔猪进行血液生理生化指标的测定，临床症状观察；选用其中2头自然感染附红细胞体仔猪，另外选用2头健康仔猪脾脏摘除后人工感染附红细胞体，进行病理解剖学和病理组织学观察。进而揭示了猪附红细胞体病对猪机体的影响程度。血液生理生化指标测定表明，仔猪显性感染阶段红细胞压积、红细胞总数、血红蛋白降低，白细胞总数升高；体温、呼吸数、心率显著增高；谷-丙转氨酶和血清胆红素升高；血糖降低。隐性感染阶段体温、呼吸、心率明显增高，其它指标也有一定程度的变化。在临床上表现出贫血、黄疸、消瘦等明显特征。自然病例的病理解剖学主要变化是血液稀薄、不易凝固，全身皮肤、粘膜和脂肪黄染，肝脏、淋巴结、脾脏肿大，及大部分器官有点状出血。病理组织学主要变化是肝脏有含铁血黄素沉积，肝细胞肿大，部分肝细胞核崩解、消失，肝细胞索排列紊乱；脾脏有含铁血黄素沉积，淋巴滤泡细胞增生，红髓大量红细胞积聚；肾脏有含铁血黄素沉积，肾小管上皮细胞变性肿胀；淋巴结有含铁血黄素沉积。自然感染附红细胞体仔猪与人工感染附红细胞体仔猪的病理学变化无明显差异。本研究为揭示猪附红细胞体的致病机理奠定了基础，为该病的临床诊断提供了科学依据。更多还原

【Abstract】 In this experiment, haematological indexes and pathological changes of pigs infected with Eperythrozoon were discussed. Physiological and biochemical indexes of blood of 20 pigs infected with Eperythrozoon were mensurated and clinical symptoms were observed. Two piglets infected with Eperythrozoon spontaneously and another two healthy piglets which were performed splenectomy and experimentally infected with Eperythrozoon were used to observe the changes of pathological anatomy and histology, and then the effects of Eperythrozoonosis to pigs were revealed.Physiological and biochemical indexes of blood showed that, the erythrocyte packed cells volume, erythrocyte total and ferrohemoglobin decreased and leucocyte total increased in the apparent stage; the temperature, respiratory frequency and heart rate increased evidently; SGPT (serum glutamate-pyruvate transaminase) and serum bilirubin increased; the blood sugar decreased. The temperature, respiratory frequency and heart rate were much higher than the normal value in the inapparent stage and other indexes had some changes in a certain extent. The clinical symptoms were characterized by anaemia, jaundice and thinness.Main pathological anatomic changes of piglets infected with Eperythrozoon spontaneously were characterized by hydremia and dys-coagulation of blood. Skin, mucosa and fat all over the body were stained yellow. Hepatomegaly, splenomegaly, tumefaction of lymphoid nodule and punctuate hemorrhage in most of organs could also be observed. Hemosiderosis in liver and spleen and kidney and lymphoid nodule were the main changes in pathological histology. Varicose liver cells partly with cracked karyon and inordinate liver cells cable existed, Lymphatic follicle cells of spleen hyperplasia, large number of red cells gathered in red pulp; epithelial cells of renal tubule denaturalized and swelled.There were not obvious differences between of the pigs infected naturally and those infected experimentally in the changes of pathological anatomy and histology. The research became the base of studying the nosogenesis of Eperythrozoonosis and supported scientific basis for diagnosis and treatment of the disease.更多还原