【作者】 邱晓玲；

【导师】 彭兆麟；

【作者基本信息】 湖北中医学院 ， 中西医结合临床儿科， 2003， 硕士

【摘要】 目的：为了评价七味白术散颗粒治疗婴幼儿轮状病毒腹泻病的疗效并初步探讨其作用机理。方法：采用随机对照的方法。应用七味白术散颗粒与思密达加丽珠肠乐对照，治疗轮状病毒腹泻婴幼儿共118例，观察临床疗效及治疗前后血清IL-2、IL-6、IL-8、T-SOD等变化。结果：七味白术散颗粒组疗效优于对照组(p＜0.05)；对重型腹泻病的疗效明显优于对照组(p＜0.01)；大便轮状病毒抗原转阴率亦高于对照组。治疗后，血清IL-2、总SOD水平升高，治疗组优于对照组(p＜0.05)；血清IL-6、IL-8水平降低，治疗组优于对照组(p＜0.05)。结论：七味白术散颗粒具有抗病毒，免疫调节和增强机体清除自由基能力的作用；具有抗炎、抗腹泻作用；疗效优于对照组，且无不良反应。值得在治疗轮状病毒腹泻病中广泛推广。更多还原

【Abstract】 Objective: To evaluate the therapeutic effect of Qiwei Baizhusan Granule(QWBZG) on infantile rotavirus diarrhea and to discover its therapeutic mechanism. Methods: The controlled observation method was adopted in the clinical study. There are 60 patients were observed in the QWBZG group .The controlled group of 58 patients was treated with Smecda and Bifidobiogen. Results: There was different in the treatment effect between QWBZG group and controlled group(p < 0.05). The QWBZG had significantly better effect on heavy patients ( p < 0.01 ) . Stool rotavirus antigen in the QWBZG group became negative more quickly than the controlled group. The serum level of IL-2 and T-SOD both rose in the two groups, but the QWBZG group was improved greatly ( p < 0.05 ) .The serum level of IL-6 and IL-8 were both decreased in the two groups, while statistical difference could be found between them(p < 0.05). Conclusion: The QWBZG is an effective and safe medicine in the treatment of rotavirus diarrhea. It has the action of anti-virus, immunoregulation and clearance of free radical. It has good effect on anti-inflammation and anti-diarrhea. It has a good prospect of development and application.更多还原