【作者】 刘龙涛；

【导师】 张文高；

【作者基本信息】 山东中医药大学 ， 中西医结合临床， 2003， 硕士

【摘要】 目的：观察不同剂量降脂红曲微粉对高脂血症的临床疗效和安全性，为降脂红曲的临床应用和开发提供科学依据。方法：80例高脂血症患者随机分为4个组，A组(降脂红曲微粉1／2剂量组)，B组(降脂红曲微粉组)，C组(降脂红曲粗粉组)和D组(血脂康组)。观察治疗前后临床症状、血脂与抗氧化、血管内皮分泌功能及肱动脉内皮依赖性舒张功能等指标变化。结果：4组用药50天后，临床症状均明显改善，A、B两组临床症状总疗效的显效率及乏力症状改善的总有效率明显优于C、D两组。各组血清总胆固醇非常显著降低，其他实验室指标亦有不同程度的改善；A、D两组降脂总有效率显著优于C组；A组甘油三酯含量显著降低，降钙素基因相关肽显著升高；A、D两组肱动脉内皮依赖性舒张功能显著改善，内皮素／降钙素基因相关肽显著降低，后4项指标其他组未见显著改变。结论：降脂红曲微粉降脂与缓解临床症状疗效肯定，安全有效，且具有抗氧化，保护血管内皮等作用，剂量可以较常规粉碎者减半，值得推广应用。更多还原

【Abstract】 Objective: To observe the therapeutic effect and security on treatment of hyperlipemia with different doses of micro-powder of lipid-reducing Hongqu(MLH), and provide scientific proof for its clinical application and development. Methods: 80 cases of hyperlipemia patients were divided randomly into 4 groups: 21 cases in Group A (MLH of 1/2 dose group), 20 cases in Group B(MLH of full dose group),19 cases in Group C(rough-powder of lipid-reducing Hongqu group) and 20 cases in group D(Xuezhikang group). To observe the changes of clinical symptoms, blood lipid , anti-oxidation, secretion function of vascular endothelium and endothelium-dependent relaxing function of brachial artery. Results: After 50 days of treatment, clinical symptoms improved in all groups, and the significant effective rate and total effective rate to tiredness of A and B groups were superior to those of C and D groups. TC in all groups reduced remarkably, and other laboratory indexes improved with different extent in each group. Total effective rate of A and B groups in reducing lipid was superior to that of C group. TG reduced and CGRP elevated in group A. Endothelium-dependent diastolic function of brachial artery improved and ET/CGRP reduced in A and D groups. Conclusion: MLH had such merits: confirmative lipid-reducing effect, relieving clinical symptoms remarkably and safely, anti-oxidation and protecting vascular endothelium. Its dose was half of the normal, and, deserved to be spread and applied.更多还原