【作者】 赵浩；

【导师】 包培荣；

【作者基本信息】 山东中医药大学 ， 中医内科学， 2003， 硕士

【摘要】 目的：观察络脉舒通颗粒剂治疗不稳定型心绞痛的临床疗效。方法：60例不稳定型心绞痛患者随机分为络脉舒通颗粒剂组（治疗组）31例，通心络胶囊组（对照组）29例。两组均用常规西药治疗，同时，治疗组予络脉舒通颗粒剂，对照组予通心络胶囊。观察治疗前后临床症状和实验室指标的变化。结果：治疗组心绞痛缓解总有效率为93.55％，显效率为70.97％；心电图疗效总有效率为93.55％，显效率为35.48％；症状改善总有效率96.77％，显效率61.29％，与对照组比较有显著性差异（P＜0.05）。显著降低TC、TG、ηbH、ηbL、ηP、Fbg，与对照组比较有显著性差异（P＜0.05或P＜0.01）。明显降低TXB₂、ET-1、APTT、TT，升高NO，与治疗前相比具有显著性差异（P＜0.05或P＜0.01）。结论：痰瘀是本病的关键病机，清热化痰、祛瘀通络是治疗不稳定型心绞痛的一种有效治疗方法。更多还原

【Abstract】 Objective: To observe the clinical effect of Luomaishutong Granule on unstable angina. Methods: Sixty patients of coronary heart disease (CHD) with unstable angina were divided randomly into treatment group (31 cases) and control group (29 cases). Conventional western medical therapy was given to both groups.At the same time, the treatment group received Luomaishutong Granule and the control group received Tongxinluo Capsule. The changes of clinical symptoms and laboratory indexes in all the patients were observed before and after treatment. Results: In the treatment group, the total effective rate of relieving angina , improving ECG and meliorating symptoms were respectively 93. 55%, 93. 55% and 96. 77%;the corresponding remarkable rate were respectively 70. 97%, 35. 48%, 61. 29%, which were significantly better than those of the control group , P<0. 05. The level of TC, TG, bH, bL, P and Fbg were decreased remarkably in the treatment group, which were statistically different compared with those of the control group, P<0. 05 or P<0. 01. Meanwhile, the level of TXB2, ET,APTT, TT were decreased and the level of NO was increased remarkably after treatment, which were statistically different compared with those before treatment. Conclusion: The phlegm and the stasis are the critical palhogenesis of unstable angina. The method of clearing heat transforming phlegm and dispelling stasis and freeing the network vessels is a main therapeutic method with positive effect.更多还原