【作者】 郭志军；

【导师】 路广晁；

【作者基本信息】 山东中医药大学 ， 中医内科学， 2003， 硕士

【摘要】 目的：观察清溃汤治疗溃疡性结肠炎(UC)的临床疗效，并从理论和临床研究两个方面系统探讨清溃汤治疗溃疡性结肠炎的机制。方法：临床选择符合纳入标准的溃疡性结肠炎患者60例，随机分为两组，中药治疗组给予清溃汤水煎剂，对照组给予SASP，观察两组的临床疗效。结果：临床研究显示，治疗组总有效率93.3％，对照组总有效率70.0％，治疗组总有效率明显优于对照组总有效率(P＜0.05)；治疗组能明显改善腹泻、里急后重、肛门灼热、腹痛、腹胀等症状，其疗效优于对照组。结论：清溃汤是治疗溃疡性结肠炎的安全有效方药，其机理可能与抗氧自由基损伤、促进溃疡面愈合、改善全身症状有关。更多还原

【Abstract】 Objective: To observe the clinical curative effect of treating ulcerative colitis(UC) with Qing-Kui-Tang and explore the mechanism of treating ulcerative colitis with Qing-Kui-Tang and explore the mechanism from theoretical and clinical aspects. Method: 60 cases with UC are divided into two groups at random. Qing-Kui-Tang is given treatment group, and at the same time SASP is given control group. Results: The totally effective rate of treatment group come to 93.3%, while that of control group is 70.0%, and there is a significant difference between the treatment group and control group (P<0.05). Treatment group can improve significantly the symptoms such as diarrhea, tenesmus, the scorch of anus, bellyache, abdominal distension, and the curative effect is better than that of control group. Conclusion: Qing-Kui-Tang is an safe and effective drug of treating UC, and the mechanism might be related to anti-oxygen free radicle injury, accelerating ulcerative recovery, improve systematic symptoms.更多还原