【作者】 肖新春；

【导师】 刘金星；

【作者基本信息】 山东中医药大学 ， 中医妇科学， 2003， 硕士

【摘要】 目的：观察益肾坤宁汤治疗围绝经期综合征的疗效并探讨其作用机理。方法：观察45例围绝经期综合征患者治疗前后临床症状改善情况，血清卵泡刺激素（FSH）、黄体生成素（LH）、雌二醇（E₂），血清微量元素锌（Zn）、铜（Cu）、铁（Fe），尿儿茶酚胺含量变化及外周血T淋巴细胞CD亚群改变情况。血清碱性磷酸酶（AKP）及空腹尿Ca/Cr的测定。结果：治疗后与治疗前相比患者症状明显改善，总有效率为95.6％，Kupperman评分治疗前后相比有显著性差异（p＜0.01）。治疗前患者血清雌二醇水平较低，卵泡刺激素和黄体生成素水平升高，治疗后患者上述指标均有明显改善。尿儿茶酚胺含量治疗后较治疗前明显降低。外周血T细胞CD亚群增加（p＜0.01）。尿Ca/Cr明显下降。（P＜0.05）结论：益肾坤宁汤具有温肾益精、滋阴降火的功效，对围绝经期综合征有较好的疗效。其治疗机理可能是通过改善下丘脑-垂体-卵巢轴的功能和调节神经系统功能、补充微量元素、改善骨代谢实现的。并且本方对围绝经期综合征患者的免疫功能亦有调节作用。更多还原

【Abstract】 Objective: To observe the curative effect of treating peripheral menopause syndrome (PMS) with trie decoction of Yi-Shen-Kun-Ning and explore the mechanism of it. Method: To observe the clinical symptoms’ improvement of 45 cases with PMS after treatment and changes of catecholamine in urine, some serum hormone such as FSH, LH, E2, some trace elements including Zn, Cu, Fe, CD subgroup of peripheral blood T lymphocytes , AKP and Ca/Cr in urine. Results: The clinical symptoms are significantly improved and the totally effective rate is 95.6%. Kupperman evaluation before treatment is significantly different from that after treatment.(P<0.01). There is a low level of E2 and a high level of FSH and LH, but there are significant changes after treatment (P<.01, P<.05). The CD subgroup of peripheral blood T lymphocytes and some trace elements such as Zn, Cux Fe is significantly increased(P<0.01,P<0.05), the catecholamine and Ca/Cr in urine is significantly decreased (P<0.01). Conclusions: The decoction of Yi-Shen-Kun-Ning can better improve the clinical symptoms of PMS. And the mechanism might be related to improve the function of hypothalamus-pituitary-ovary axis, regulating nerve system and increasing the trace elements. Besides, the decoction of Yi-Shen-Kun-Ning can regulate the function of immune system.更多还原