【作者】 王桂娟；

【导师】 曹志群；

【作者基本信息】 山东中医药大学 ， 中医内科学， 2002， 硕士

【摘要】 本文目的在于探讨溃结康治疗溃疡性结肠炎的疗效和作用机理。随机设溃结康治疗组46例，柳氮磺胺吡啶(SASP)对照组44例，作临床对比观察，并进行动物实验研究。 临床结果：治疗组临床完全缓解率60.9％，有效率91.3％，优于对照组40.9％，70.5％，P＜0.01。在缓解临床症状体征方面，治疗组优于对照组，P＜0.01。在免疫指标方面，溃结康能使患者异常增生的IgG明显降低，低下的IL—2水平提高，CD4/CD8比值明显低于对照组，接近正常水平。 动物实验结果表明：溃结康能明显降低造模大白鼠IgG值，明显升高IL—2值，能促进造模大白鼠溃疡的愈合，对腹泻小鼠有明显的止泻作用。 溃结康通过改善体内IgG、IL—2水平及CD4/CD8比值来调节机体的免疫功能，恢复体内免疫内环境的平衡，并有良好的促进溃疡愈合及止泻止血作用，是治疗溃疡性结肠炎的有效方剂。更多还原

【Abstract】 The article mainly discussed the therapeutic effect and mechanism of kuijiekang in treating ulceratic colitis. Clinical observation were carried ,in which treatment group (46cases)vvith kuijiekang and contract group (44cases)\vith Salicylazosulfapyridine(SASP) were set up randomly.Resuh:Treatment group had 60.9 percent in clinical complete alleviated rate and 91.3 percent hvoffei ive rate , superior to contrast group with 40.9percent and 70.5 percent respectively . The’probability is less than 0.01.Treatmeat group is also superior to contrast group in alleviating symptoms and signs ,the probability is less than 0.01.Kuijiekang can decrease the level of IgG obviously,increase the level of IL-2,can make the level of CDS higher than contrast group,make ratio between CD4and CDS lower than contrast group,reach the normal level.The result of animal experiment indicated that kuijiekang decreased the level of IgG in animal model obviously,increased the level of IL-2 obviously,can accelerate the ulcer’s healing and treat diarrhea of mouse.Kuijiekang can regulate immune function ,recover the immune balance,and had good function in accelerating the ulcer’s healing and arresting diarrhea through improving the level of IgG and IL-2,the ratio between CD4and CD8. So Kuijiekang is an effective docoction in treating ulcerative colitis.更多还原