【作者】 刘春海；

【导师】 罗杰英； 杨永华；

【作者基本信息】 湖南中医学院 ， 中药学， 2002， 硕士

【摘要】 本论文对药物在复方汤剂中一些化学成分浸出率变化的影响因素进行了初步的研究。采用正交试验，应用HPLC、HPCE、AAS等检测方法测定了药物一些化学成分在汤剂中的含量。 试验研究结果表明，质地坚硬的矿物类、角甲类药物，如紫石英、鳖甲在复方汤剂中的煎煮条件为粉碎过60目，加10倍量水，先煎1.5～2小时；毒性药物如附片则先煎30分钟即可达到安全限量；其他需要先煎的药物如麻黄，以先煎2次，每次15分钟为宜。同样，后下类药物如大黄、厚朴则以药材浸泡30分钟，后下煎煮10分钟为宜。 综上所述，不同的药物在复方汤剂煎煮过程中其化学成分的浸出率影响因素不同，应视不同条件予以分别对待。更多还原

【Abstract】 The thesis do some preliminary studies on influencing factors of macerational rate of chemical compostion for Chinese herbal medicine in compound decoction. We apply the orthogonal test and determine contents of chemical compostion in the decoction by using some advanced detection method such as HPLCx HPCE and A AS etc. The experimental results show:the mineral medicine and the animal medicine which having rigid texture,for example Fluoritum and Carapax Trionycis,should be broken into 60 mesh,added 10 doubles water and decoctered first 1.5-2 hours.The toxic drugs such as Radix Aconiti Lateralis Preparata can reach the safe limit after being decoctered first 30 minutes.Other drugs such as Herba Ephedrae should be decoctered first twice and 15 minutes every time.Likewise,Radix Et Rhizoma Rhei and Cortex Magnoliae Officinalis with being decoctered later 10 minutes is best.In conclusion,different drugs should be treated respectively owing to their diverse influencing factors of lixiviated rate of chemical compostion in decoctional process of the compound decoction.更多还原