【作者】 王天民；

【导师】 陈大舜；

【作者基本信息】 湖南中医学院 ， 中医内科学， 2002， 硕士

【摘要】 目的：探讨在归降糠灵对实验性糖尿病(DM)大鼠脂质过氧化损伤的影响并阐述其治疗糖尿病的可能作用机理之一。方法：实验大鼠随机分组，治疗组以左归降糠灵灌胃治疗，对照组分别以中、西药物愈三消、达美康进行灌胃处理。观察了左归降糖灵对小剂量链脲佐菌素和高热量饲料诱发的糖尿病大鼠血和肾组织中丙二醛(MAD)含量，谷胱苷肽过氧化物酶(GSH—PX)活性、超氧化物歧化酶(SOD)活性的影响。结果：左归降糖灵有明显的降低大鼠血清MDA含量，提高大鼠全血及肾组织中GSH—PX活性，提高大鼠红细胞及肾组织中SOD活性的作用，与对照组比较差异有统计学意义(P＜0.05，P＜0.01)。结论：以阴阳互济法则确立的左归降糖灵是治疗糖尿病的有效经验方，可显著对抗实验性糖尿病大鼠的脂质氧化损伤。更多还原

【Abstract】 Objective: To investigate the Anti-Lipid Peroxidation Impairment Effect of Zuoguijiangtangling (ZGJTL) Decoction on experimental diabetes among rats, and to explore the possible therapeutic mechanisms for this lesion. Methods: The DM rats model was reproduced by abdominal injection with streptozotocin (STZ)40mg/kg and feeding with high calorie animal feeds. Then the rats with experimental DM were divided into treating group and 2 controlling groups randomly. The experimental group was treated with ZGJTL decoction and the controlling groups were treated with YuXanXiao or DaMeiKang respectively. The activity of glutathione peroxidase (GSH-PX), superoxide dismutase (SOD)and the content of malonic aldehyde (MAD) in kidney tissue and blood were detected by different methods respectively during the process of experiment. Results: ZGJTL had significant effects on the induced MD among model rats as follows: decreasing obviously the content of MDA in blood serum, as a result ofobviously increasing the activity of SOD in kidney tissue and red blood cell (RBC), and increasing the activity of GSH-PX in the blood and kidney tissue. The differences of all the findings observed in the experiments were very significant when compared between the experiment group and controlling groups( /)<0.05P<0.01 ). Conclusions: The ZGJTL prescription formulated on the base of the principle of enriching Yin and Yang is very effective on MD, and it holds obvious therapeuticeffect of anti-lipid peroxidation impairment on experimental diabetes for model rats.更多还原