【作者】 杨怡卓；

【导师】 杨守范；

【作者基本信息】 黑龙江中医药大学 ， 中医妇科学， 2002， 硕士

【摘要】 目的：探讨绝经后妇女施以“抗骨松冲剂”对骨量、骨代谢生化指标的影响。方法：将56例绝经后妇女随机分为2组，即“抗骨松冲剂”组和尼尔雌醇组。用药12周后，进行腰椎骨密度（BMD）测定和血生化及放免指标检测。结果：与实验前自身比较，（1）“抗骨松冲剂”组，BMD明显增加（P＜O.01），而代表骨形成及骨吸收指标下降（P＜0.05），雌二醇（E₂）增加（P＜0.05）。（2）尼尔雌醇组，BMD明显增加（P＜0.01），雌二醇（E₂）明显增加（P＜0.01）。同时，“抗骨松冲剂”组与尼尔雌醇组比较，BMD增加（P＜0.05），雌二醇（E₂）明显下降（P＜0.01）。结论：抗骨松冲剂与尼尔雌醇均能阻止绝经后妇女的骨量丢失，且“抗骨松冲剂”在促进骨形成、增加骨量方面优于尼尔雌醇，而无尼尔雌醇的致子宫内膜增生等副作用，是一种较理想的治疗绝经后骨质疏松症的药物。更多还原

【Abstract】 Objective: To observe the influence in bone mass and the values representing bone metabolic biochemistry after postmenopausal women are treated with Kang Gu Song Granule. Methods: fifty six postmenopausal women were randomly divided into two groups i. e. Group I : treated with Kang Gu Song Granule. Group II: treated with Nylestriol. In the twelfth week, such items were measured as bone density(BMD) of abdominal vertebrae^ biochemistry> radioimmuoassay.Results: Compared with themselves before twelve weeks, (l)Kang Gu Song Granule group, the bone density increased significantly while the values representing bone form and bone absorption decreased, the content of estradiol increased. (2)Nylestriol group, the bone density increased distinctly, the content of estradiol increased significantly. At the same time, Comparing Kang Gu Song Granule group with Nylestriol group, the bone density increased, the content of estradiol decreased significantly.Conclusions: Both Kang Gu Song Granule and Nylestriol can prevent bone loss of postmenopausal women while Kang Gu Song Granule was superior to Nylestriol in promoting bone form and increasing bone mass and bearing no side effects of endometrial proliferation which may be induced by Nylestriol, so it is a promising drug for the treatment of postmenopausal osteoporosis.更多还原