【作者】 鞠宏；

【导师】 赵堪兴；

【作者基本信息】 天津医科大学 ， 眼科学， 2002， 硕士

【摘要】 目的 应用多焦视网膜电图（mERG）及图形视觉诱发电位（P-VEP）探讨弱视的视网膜及视中枢损害。 方法使用VERIS 4.2视诱发反应图象系统和NICOLET compact 4视觉电生理检测仪对28例屈光参差性弱视，25例斜视性弱视、14例屈光不正性弱视儿童进行mERG和P-VEP的检测，并与正常对照组比较。对mERG一阶反应，二阶反应的N₁波、P₁波的振幅密度、潜时进行四组间比较、两两组间比较、不同视网膜区域间比较。对屈光参差性弱视组、斜视性弱视组的重度与轻、中度弱视的mERG指标进行比较。对弱视组视力与mERG指标进行相关分析。刘屈光参差性弱视组、斜视性弱视组的好眼与患眼、好眼与正常组的mFRG指标进行比较。对P-VEP P₁₀₀波振幅、潜时进行四组间比较、两两组间比较。 结果三种类型弱视的mERG一阶反应P₁波、N₁波、二阶反应的P-1波均表现振幅降低，在视野中央较显著，这种改变随离心度的增加而减少。正常组颞上、颞下视野一阶反应P₁波、N-1波潜时较鼻上、鼻下视野延长，鼻下视野振幅密度较颞上视野高。四组均表现颞侧视野一阶 反应P；波、N；波振幅密度较鼻侧视野降低，颖侧视野潜时延长。四组 二阶反应P；波振幅密度上半视野低于下半视野，其余指标上半、下半视 野差异无显著性。弱视组与正常组间＊＊＊G潜时比较差异无显著性。三 种类型弱视间mERG比较差异无显著性。轻、中度弱视与重度弱视mERG 差别无显著性。弱视患者视力与mERG指标之间无线性相关关系。弱 视组好眼mERG指标与患眼差别有显著性，与正常组相比差别无显著 性。弱视的 PVEP P1＊波潜时延长，振幅降低。三种类型弱视间 PVEP P；；。波比较差异无显著性。 结论①三种类型弱视mERG二阶反应的 P；波振幅密度比正常对照 组降低，且在视野中央较显著，这种改变随离心度增加而减少，支持弱 视X神经节细胞受损学说。②弱视组与正常组mERG潜时差异无显著 性，提示神经信屈、的传递在视［f4膜内无延长。PVEP P；。。波潜时延长主 要发生在视网膜到视皮层的传寻时问，视网膜内反应时间无延长。③本 文中加。｝厂，；。ERG对训附野小问区域比较的意义，四个象限之间，鼻侧。 颚侧千W之间，卜丫、卜IW0 之问 士 人在刁对称现象。④本研亨击明 弱视服卜VEP比厂发组P；W波潜时延长，振幅降低，支持弱视视中枢和 传导系统存在异常。 因而本研究结果支持弱视发病机制既存在视网膜困素也存在视中 枢因素。 2 弱视眼外层视网膜是否受损，不同程度弱视之间视网膜受损程度是否不同，不同类型弱视发病机制的差别存在于何种水平(中枢、外周入单侧弱视患者的好眼视网膜是否正常有待进一步研究。更多还原

【Abstract】 Objective To investigate the characteristic of the multifocal electroretinogram and pattern visual evoked potentials in amblyopic eyes.Methods The mERG and P-VEP of 28 anisometropic amblyopic eyes, 25 strabismic amblyopic eyes, 28 isometropic amblyopic eyes and 54 normal control eyes were tested.Results The NI wave and P, wave amplitude densities of mERG first order kernel and the PI wave amplitude densities of second order kernel in amblyopic eyes were significantly attenuated in the central region of the visual field, and these phenomena gradually reduced with the increase of the eccentricity. The NI wave and PI wave latencies of mERG first order kernel at the superior-temporal and inferior- temporal quadrant visual field were delayed than at the superior-nasal and inferior- nasal quadrant visual field in control eyes. The NI wave and PI wave amplitude densities of mERG first order kernel at the inferior- nasal quadrant visual field were larger than at thesuperior-temporal quadrant visual field. The N, wave and PI wave amplitude densities of mERG first order kernel at the temporal visual field were smaller than at the nasal visual field, and the latencies were delayed at the temporal visual field in all groups. The Pt wave amplitude densities of mERG second order kernel at the upper visual field were smaller than at the lower visual field in all groups, and other indexes were not statistically significantly different between the upper visual field and the lower visual field. Latencies of mERG among all groups were not significantly different. No significant difference of mERG was found among the three types of the amblyopic eyes. No significant difference of mERG was found between mild amblyopia and serious amblyopia. There were no linear correlations between visual acuity in amblyopic eyes and the indexes of mERG. There were significant differences between the sound eyes and the amblyopic eyes in mERG, but there were no significant differences between the sound eyes and the control eyes. The P|0o amplitudes of P-VEP in amblyopic eyes were significantly attenuated. The P)0o latencies of the P-VEP in amblyopic eyes were significantly delayed. No significant difference of P-VEP was found among the three types of the amblyopic eyes.Conclusions The results suggested that the pathological mechanism ofamblyopia might exit in both the retina and the visual cortex. The X ganglion cells in the retina of amblyopic eye were abnormal. The visual information transmitting time was normal in the retina of amblyopic eye. There were abnormal development and function in visual cortex. The mERG and P-VEP were objective methods for assessing visual function in amblyopia.更多还原