【作者】 孙慧斌；

【导师】 李宁毅；

【作者基本信息】 青岛大学 ， 口腔临床医学， 2001， 硕士

【摘要】 目的：研究糖尿病患者唾液中葡萄糖、钙、镁含量的改变，并观察唾液糖与血糖的关系，研究糖尿病患者牙周病的发病率，旨在研究糖尿病与牙周病的密切关系。方法： 实验组为60例糖尿病人，对照组为60例正常人。对实验组及对照组行口腔检查，记录牙周病指数(PDI)，观察牙周病发病率；收集清晨非刺激状态下自然分泌的全唾液，进行葡萄糖、Ca++、Mg++ 含量分析，同时行空腹血糖分析。结果：糖尿病组的牙周病发病率为70%，明显高于对照组38.33%，二者有显著性差异（P<0.05〉。糖尿病组的唾液葡萄糖含量为1.950±0.179mmol/L，高于对照组的0.953±0.124mmol/L，二者有显著性差异P<0.01。糖尿病组的唾液钙含量为1.868±0.193mmol/L，高于对照组的0.959±0.127mmol/L，二者有显著性差异P<0.01。糖尿病组的唾液镁含量为0.551±0.093mmol/L，高于对照组的0.204±0.037mmol/L，二者有显著性差异P<0.01。糖尿病组的唾液葡萄糖含量与血糖浓度有显著直线相关性P<0.05。但是糖尿病组的唾液葡萄糖含量与牙周病指数（PDI）之间未发现明显相关性P>0.05。结论：1.糖尿病患者唾液中的葡萄糖、钙、镁含量明显增加，说明唾液腺分泌功能发生改<WP=4>变，这可能是机体在长期高血糖状态下对唾液腺的损害，唾液成分含量的改变对牙及牙周组织的破坏起了一定的作用。2.糖尿病患者的牙周病发病率明显高于正常人，说明在高血糖状态下牙周组织易于受到破坏，这与糖尿病人本身的代谢异常有关。糖尿病是造成牙周病多发的一个重要的危险因素。以上两点也可视为糖尿病这一全身性代谢疾病的口腔局部表现。更多还原

【Abstract】 Department of stomatology , Medical College, Qingdao UniversityPostgraduate Sun HuibinTutor Li Ningyi ProfessorObject To analysis the high level of glucose ,calcium and magnesium concentration in salivary, In order to study the relationship between the level of blood glucose and salivary glucose. To study the percentage of periodontal diseases in patients with diabetes mellitus. In order to study the relationship between diabetes and periodontal disease. Method The experiment group is 60 patients with diabetes mellitus;The control group is 60 healthy subjects. The condition of oral health is examined to find the percentage of periodontal disease. Blood glucose levels and the glucose, calcium and magnesium concentration in unstimulated mixed salivary taken from testee are measured. Results The percentage of periodontal disease in diabetes group is 70%, in control group is 38.33%. The percentage of periodontal diseases is statistically significant in experimental and control group. The average values of salivary glucose concentration in experimental group is 1.950±0.179mmol/L,in control group is 0.953±0.124 mmol/L. The salivary glucose concentration is statistically significant in experimental and control group. The average values of salivary calcium concentration in experimental group is 1.868±0.193 mmol/L, in control group is 0.959±0.127mmol/L. The salivary calcium concentration is statistically significant in experimental and control group. The average values of salivary magnesium <WP=6>concentration in experimental group is 0.551±0.093mmol/L, in control group is 0.204±0.037mmol/L. The salivary magnesium concentration is statistically significant in experimental and control group. Linear regression of salivary glucose on blood glucose gives a statistically significant correlation coefficient of 0.210(P<0.05). But linear regression of PDI on salivary glucose gives a simple correlation coefficient of 0.7873(P>0.05). Conclusion The salivary glucose, calcium and magnesium concentration in patients with DM is significant higher than the levels of healthy subjects. It indicates the secretion function of salivary gland may be destroyed under the status of high blood glucose. The percentage of periodontal disease in patients with DM is higher than in healthy subjects. It indicates the diabetes is one of the dangerous factors in the development of periodontal disease.更多还原