清开灵注射液治疗活动期类风湿性关节炎的临床及实验研究

【作者】 庞爱梅；

【导师】 杜秀兰；

【作者基本信息】 山东中医药大学 ， 中医内科学， 2001， 硕士

【摘要】 目的：探讨清开灵注射液（简称清开灵）治疗活动期类风湿性关节炎（RA）的机理。方法：将70例确诊为类风湿性关节炎的患者随机分为清开灵治疗组38例，火把花根片对照组32例，对其症状、体征及实验室检查作治疗前后对比。采用Ⅱ型胶原免疫Wister大鼠诱发的关节炎模型（CIA），观察清开灵对CIA大鼠足肿胀的影响及关节病理的变化；并观察了其对大白兔的退热作用、对小鼠纸片肉芽肿的影响和镇痛的作用。结果：临床治疗组总有效率为89.47％，对照组总有效率为87.5％，两组总有效率比较差异不显著（P＞0.05）。但在退热方面，清开灵组明显优于火把花根片组（P＜0.01）。动物实验表明清开灵具有解热、抗炎、镇痛、免疫调节作用。组织病理学改变示滑膜组织增生及炎症细胞浸润程度较模型组减轻。结论：清开灵可用于活动期类风湿性关节炎的治疗。更多还原

【Abstract】 Objective: To explore the mechanism of Qingkailing injection (QKLI) in treating rheumatiod arthritis(RA) in active stage. Methods: Seventy cases of RA in active stage were divided into the treated group (38 cases treated with QKLI) and the control group(32 cases treated with HuoBaHuaGen tablet). The syptonis-. signs and laboratory examinations of all patients before and after treatment were observed. In experiment study,severity of arthritis and the arthritic index were investigated in the wister rats with collagen-induced arthritis (CIA) and in mice. In addition, observation of antifebric effect on rabbits was also made.Results: The total effective rate was 89.47 % in treatment group,while in control group,it was 87.5 %. The difference of total effective rate between the two groups was unremarkable (P>O.05), while QKLI is superior to HuoBafluaGen tablet in effect of antifebric. Experiments on animals showed QKLI has the function of antifebric~ dephlogisticate -~ anigesia and immune regulation. I[Iistopthology showed that less synovium hyperplasia and fewer infiltration of inflammatory cells in the group treated with QKLI than the control group. Conclusion:QKLI can be applied to the therapy of RA in. active stage.更多还原