更年乐治疗更年期综合征的实验研究

【作者】 王红；

【导师】 吴高媛；

【作者基本信息】 天津中医学院 ， 中医妇科， 2000， 硕士

【摘要】 更年期综合征是一种临床常见病、多发病，导师吴高媛教授在中医理论指导下，总结多年临证心得，认为“肾虚肝郁、冲任虚损”是其主要病机，并据此确立了“滋肾柔肝、调补冲任”的治疗大法，自创更年乐治疗本病，临床取得了很好的疗效。本文通过实验研究进一步证实其临床疗效，并揭示其作用机理。 结果表明，更年乐可降低更年期大鼠血中FSH、LH水平，提高下丘脑及血中的β-EP水平，增加子宫ER含量，从而调节下丘脑—垂体—卵巢—子宫轴的功能。并通过增加脾细胞ER水平，使雌激素更好地调节免疫功能，提高机体的免疫力，进而使神经—内分泌—免疫网络处于一种稳态。更多还原

【Abstract】 Climacteric Syndrome (C 5) is a kind of common and recurrent disease clinically. On the basis of T C M theory and clinical experience of many years, professor Wu Gaoyuan pointed out that “kidney-asthenia and liver depression, impairment of chong and ren channels”is the main pathogenesis of C S. Then, She proposed the “nourish the kidney and soothe the liver, invigorate Chong and ren channels”treatment principle. According to this principle, “Geng Nian Le”was made to treat C S and acquired a good curative effect. This thesis went a step further to demonstrate its curative effect and reveal its mechanism of action through experimental research. The results showed that“Geng Nian Le”can reduce the serum FSH and LH level of menopausal rats, raise their β-EP level of hypothalamus and serum while improve their ER level of uterus, and then regulate the function of hypothalamus-hypophysis-ovary-uterus axis. It also can make estrogen regulate immune function through improving ER level of spleen. Thus, the Neuroendocrine-immune Network will be in stable state.更多还原