【作者】 王盛柳；

【导师】 刘莲英；

【作者基本信息】 北京化工大学 ， 材料科学与工程， 2012， 硕士

【摘要】 分散聚合两步法是一种新的，具有发展潜力的制备单分散表面含功能基团微球的方法。利用分散聚合制备出来的功能微球在后续的运用中能制备出不同微球结构及形貌的材料，所制备出的材料可应用于粘结材料，纳米装载材料，生物材料及光感材料等研究领域中。本论文采用了分散聚合两步法及多步法制备了表面含有亲水单体DMAEMA,光引发单体BPMA, DBPMA等功能单体的核壳微球，并通过分散聚合两步法研究了提高微球表面功能基团含量的方法。通过研究微球在聚合过程中的形貌、结构的变化讨论了分散聚合两步法的核壳结构形成机理。在DBPMA即可作为交联剂又可作为光引发的基础上通过分散聚合两步法-自模板法制备出了表面层为交联结构的核壳微球，调节溶剂作用时间下得到了微球内部为网状结构及空心结构的功能微球。通过分散聚合两步法/多步法制备出的光引发功能核壳及中空微球在UV光的照射下耦合上不同链长度的亲水单体PEG(200,4000)以改变微球表面的亲水性，同时还讨论了在不同搅拌环境下制备出的微球表面形貌的变化；或耦合上BSA、IgG等一类生物大分子，并对其做抗原-抗体匹配试验以改变微球表面的生物相容性。中空粒子具有很好的腔体结构且微球壳层微球多孔结构，在此基础上本论文还讨论了向中空微球装载磁性粒子，以实现有机/无机纳米粒子的相结合。更多还原

【Abstract】 Dispersion polymerization is a new and potential technique for preparingmonodispersity particles with functional group in the surface. The functionalparticles were synthesized by Two-stage dispersion polymerization could beuse to prepare different materials with different structure and morphology.These materials can be applied to in the field of research such as the bindingmaterial, nano loading materials, biological materials and light sensormaterials.We use Two-stage dispersion polymerization to prepare core-shellfunctional particles which surface contained hydrophobic monomer (BPMA orDBPMA) or hydrophilic monomer (DMAEMA) in this paper. We also usedthis method to study a way to increase the content of functional group ofparticles surface. This paper discussed core-shell structure formationmechanism through study the change of structure and morphology of pariticlesin process of two-stage dispersion polymerization. Our research uses a newfunctional monomer which contains structure of benzophenone (BP) and twodouble bonds which called DBPMA. PSt-core was prepared at first stagedispersion polymerization and poly (St-DBPMA)-shell was constructed byslowly adding St/DBPMA mixture into reactor after3h polymerization.Moreover, cross-linked hollow particles could be prepared by removing corein THF and different dissolved time could prepare different Mesh structureand hollow structure particles.We introduced photoreactive agent into the surface of nanoparticles andcross-linked hollow nanoparticles could be further modified by photograftingpolymerization. Core-shell/Hollow particles were exposed to UV light cancouple with protein likes biological macromolecules (BSA), water-solubleoligomer (PEG) and mouse IgG, and hollow particles can be used as a carrierto load magnetic nanoparticles.更多还原