【作者】 吴金珠；

【导师】 孔薇；

【作者基本信息】 南京中医药大学 ， 中医内科学， 2012， 硕士

【摘要】 慢性肾小球肾炎(CGN),简称慢性肾炎,临床上以蛋白尿、血尿、高血压和水肿为基本表现。其起病方式各有不同,病情迁延,进展缓慢,终至慢性肾衰竭。本病中,肾虚湿热是慢性肾炎重要的病理特征,湿热既是致病因素,又是病理产物。益肾清利颗粒由黄芪、白术、山萸肉、杜仲、泽泻、白花蛇舌草等组成,全方补肾益气,清热利湿。故以益肾清利之法-益肾清利颗粒治疗慢性肾炎肾虚湿热证。一、益肾清利颗粒对于大鼠Heymann肾小球肾炎的作用以益肾清利颗粒、肾炎康复片治疗Heymann肾小球肾炎大鼠,测尿常规(尿蛋白、尿红细胞)、24小时尿蛋白定量、肾功能(肌酐、尿素氮)、肝功能(总蛋白、白蛋白)的水平及治疗前后的动态变化。结果表示：益肾清利颗粒显著减低24小时尿蛋白及肌酐,升高血清白蛋白；该药降低血清肌酐、升高血清白蛋白的作用优于肾炎康复片。二、益肾清利颗粒对于大鼠C-BSAⅠ肾小球肾炎的作用以益肾清利颗粒、肾炎康复片治疗C-BSAⅠ肾小球肾炎大鼠,检测尿常规(尿蛋白、尿红细胞)、24小时尿蛋白定量、肾功能(肌酐、尿素氮)、肝功能(总蛋白、白蛋白、胆固醇、甘油三酯)的水平及治疗前后的动态变化。结果表示：益肾清利颗粒可以降低24小时尿蛋白及血肌酐,对于白蛋白的降低趋势、胆固醇的升高趋势有一定改善作用。该药可显著降低胆固醇,效果早于、优于。肾炎康复片。三、益肾清利剂对慢性肾小球肾炎。肾虚湿热证患者的临床效果本文研究了16例慢性肾小球肾炎肾虚湿热证患者,给予常规治疗+益肾清利剂治疗,观察其中医症候、临床症状,检测尿常规(尿蛋白、尿红细胞)、24小时尿蛋白定量、肾功能(肌酐、尿素氮)、肝功能(总蛋白、白蛋白、胆固醇、甘油三酯)的前后变化。结果表明：治疗前后,其中医症候、临床症状显著改善,尿常规(尿蛋白、尿红细胞)、24小时尿蛋白定量等指标均显著降低。该药疗效显著,并可显著改善患者生存质量。更多还原

【Abstract】 Chronic glomerulonephritis, abbreviated to chronic nephritis, hematuria, edema, high blood Pressure as the main clinical manifestation,different onset of ways, protracted, slow progressed, and eventually will be developed to the chronic renal failure. In this disease, Dampness-heat and Kidney deficiency is important pathologic characteristic of chronic nephritis.Dampness-heat is both pathogenic factor and pathological product. Yi shen qing li Granule is consists of astragalus membranaceus, atractylodes macrocephala koidz, cornus officinalis, eucommia, oriental waterplantain rhizome, hedyotis diffusa and other traditional chinese medicine,which clears away heat,promotes dampness and tonifies Qi of the kidney.Thus Yi shen qing li Granules treat chronic glomerulonephrit of Dampness-heat with Kidney deficiency syndrome with the method of tonifiying Qi of the kidney,clearing away heat and promoting dampness.A、Yi shen qing li Granule for the rats particles Heymann glomerulonephritis roleTo Yi shen qing li Granule, shenyan kangfu pian treatment Heymann glomerulonephritis rats, Testing routine urine (urine protein, urinary red blood cells),24-hour urinary protein quantitative, renal function (serum creatinine, urea nitrogen), liver function (total protein, albumin, cholesterol, triglyceride) and the dynamic changes between before and after treatment. The results said:Yi shen qing li Granule obviously decreases the particles24-hour urine protein and serum creatinine, increases serum albumin, this drug reduceing serum creatinine,and increasing the role of serum albumin is better than the nephritis of rehabilitation.B、Yi shen qing li Granule for the rats C-BSA glomerulonephritis roleTo Yi shen qing li Granule, shenyan kangfu pian treatment C-BSA glomerulonephritis rats, Testing routine urine (urine protein, urinary red blood cells),24-hour urinary protein quantitative, renal function (serum creatinine, urea nitrogen), liver function (total protein, albumin, cholesterol, triglyceride)l and the dynamic changes between before and after treatment. The results said:Yi shen qing li Granule can reduce24-hour urinary protein and serum creatininc, to reduce the trend of albumin, rising trend for cholesterol have improved.C、To observe the clinical effects of Yi shen qing li Granule In treating Patienis with Dampness-hot and Kidney deficiency syndrome in chronic glomerulonephritis.This paper studies16patients of syndrome of Dampness-hot and kidney deficiency of chronic glomerulonephritis,they are treated by routine treatment+Yi shen qing li Granule. Observe the TCM symptoms, the clinical symptoms, test routine urine (urine protein, urinary red blood cells),24-hour urinary protein quantitative, renal function (serum creatinine, urea nitrogen), liver function (total protein, albumin, cholesterol, triglyceride)l and the dynamic changes of the before and after treatment. The results show that:before and after treatment, the TCM symptoms, the clinical symptoms improved significantly, routine urine (urine protein, urinary red blood cells),24hour quantitative indices such as urinary protein were significantly reduced.更多还原