【作者】 陈莹；

【导师】 刘秋庭；

【作者基本信息】 湖南中医药大学 ， 中西结合临床， 2012， 硕士

【摘要】 目的：探讨苦碟子注射液对急性脑梗死患者的临床疗效及对血清炎症因子hsCRP、IL-18影响的临床研究。方法：选择适当病例,将60例急性脑梗死患者采用随机对照的方法分为两组；对照组30例予抗血小板聚集、改善脑水肿及脑循环、清除氧自由基,防止钙超载等方法,治疗组30例在此基础上加用苦碟子注射液进行治疗,14天为一疗程,分别在治疗前和治疗后采用ELISA法检测两组前后血清hsCRP,IL-18的含量变化,同时评价患者治疗前后神经功能评分、日常生活Barthel指数评分和中医证侯评分及疗效,进行统计学分析。结果：①治疗前后两组的神经功能评分有显著差异(P<0.01)；②治疗前后两组的日常生活Barthel指数有显著差异(P<0.01)；③中医证侯评分及疗效治疗前后有差异(P<0.05)；④治疗后两组血清hsCRP,IL-18的含量较治疗前均有下降(P<0.05),但治疗组血清hsCRP,IL-18的含量较对照组下降更加明显(P<0.01)：⑤治疗前后血清hsCRP,IL-18的含量有明显相关性(P<0.01)。结论：(1)苦碟子注射液可以促进急性脑梗死患者神经功能恢复、改善日常生活Barthel指数、中医证侯评分及疗效,改善急性脑梗死患者的生存质量。(2)苦碟子注射液能降低急性脑梗死患者血清hsCRP、IL-18的含量,治疗作用之一可能可以通过降低血清炎症因子hsCRP、IL-18对脑的损伤,对脑组织起保护作用。更多还原

【Abstract】 Objective:Clinical research on effects of Bitter dish injection liquid to serum hsCRP、IL-18of patients with acute cerebral infarction.Method:Set appropriate into and exclusion standard, about the chosen by the method of case randomized,60patients with acute cerebral infarction patients were randomly divided into two groups.30cases of the comparison group was treated with methods of anti-platelet aggregation and improve brain edema and cerebral circulation, removing oxygen free radicals, preventing calcium overload and so on, the treatment group in this foundation of30cases of combined with bitter dish injection for treatment,14days as one period of treatment, Changes of the serum hsCRP, IL-18content in the two groups were tested before and after treatment respectively by ELISA method., at the same time to assess statistical analysis were carried out on neural function scores, daily life activities Barthel index, TCM syndrome score and outcome before and after treatment.Results:(1) The neurobehavioral scores, before and after treatment, in the two groups are different.(P<0.01);(2) Barthel index before and after treatment, of the two groups neurobehavioral scores significant Have significant difference (P<0.01);(3) TCM syndrome score and outcome, before and after treatment, have also significant difference (P <0.05),(4) After treatment, both the serum hsCRP、IL-18content of the two groups decreased (P<0.05), but the decrease of that in the treatment group is larger (P<0.01);(5)Before and after treatment hsCRP serum, IL-18in a significant relationship (P<0.01).Conclusion:(1) Bitter dish injection in the treatment of patients with acute cerebral infarction, can promote recovery of neural function, improve the Barthel index of daily life and curative effect of TCM syndrome type, so as to improve survival quality of patients with acute cerebral infarction.(2) Bitter dish injection can reduce serum hsCRP, IL-18, and one of the treatment effect of them may can reduce serum inflammation factors through hsCRP、IL-18to brain damage,the protection of brain tissue.更多还原