【作者】 刘玉洁；

【导师】 陈世义；

【作者基本信息】 吉林大学 ， 临床医学， 2012， 硕士

【摘要】 背景：掌跖脓疱病是一种病因尚未完全明了的发生于掌跖部位的慢性、复发性、炎症性疾病。多数人认为免疫学介导的发病机制在掌跖脓疱病的发生上起着重要的作用，但也有人认为本病是一种局限性脓疱型银屑病。本病的典型临床表现是在红斑基础上周期性发生的深在无菌性小脓疱,伴角化、脱屑。治疗方法多样主要有维甲酸类、免疫抑制剂、生物调节剂，抗生素类以及物理疗法，但疗效都不十分满意。阿维A联合雷公藤多甙治疗掌跖脓疱病的国内相关报道较少。目的：观察阿维A联合雷公藤多甙治疗掌跖脓疱病疗效和安全分析。方法：搜集门诊患者102例，随机分成三组：分别为阿维A联合雷公藤多甙组、阿维A组、雷公藤多甙组，同时均外用复方丙酸氯倍他索软膏（商品名：金纽尔）疗程2月，然后根据各项治疗指标进行比较。结果：阿维A联合雷公藤多甙组治疗2个月后有效率明显高于另外两组（阿维A联合雷公藤多甙组为92.31%，阿维A组为64.52%，雷公藤多甙组为62.5%），阿维A联合雷公藤多甙组与阿维A组相比（X~2=9.092，P=0.028<0.05）差异有统计学意义；阿维A联合雷公藤多甙组与雷公藤多甙组相比（X~2=11.084，P=0.011<0.05）差异有统计学意义；阿维A组与雷公藤多甙组相比（X~2=0.575，P=0.902＞0.05)差异无统计学意义。结论：与单用阿维A或者雷公藤多甙相比两药联合应用治疗掌跖脓疱病疗效高，不良反应无明显增加。更多还原

【Abstract】 Background: palmoplantar pustulosis is a disease that have still not fullyunderstand its pathogeny, occurs in the palms and soles, it is a chronic,relapsing, inflammatory disease. Most people think that the pathogenesis ofimmunology plays an important part in palmoplantar pustulosis, but also somepeople think that the disease is localized pustular psoriasis.The typical clinicalperformance is small, sterile, deeply pustules occurred periodic based inerythema, with keratinize and take off bits. Treatment methods are various，forexample Tretinoin、immunosuppressive agents、biological regulator、antibiotic and physical therapy，but curative effect is still not quite satisfiedwith.The report about palmoplantar pustulosis treated with Acitretin andTripterygium Glycosides is rarely.Objective：To observe the efficacy of palmoplantar pustulosis treated withAcitretin and Tripterygium Glycosides.Methods:102out-patients were randomly divided into3groups whichwere treated by Acitretin and Tripterygium Glycosides, Acitretin,Tripterygium。At the same time all use compound clobetasol propionate ointment externally intwo months，and then to compare treatment datas。Results: The effective rate of Acitretin and Tripterygium Glycosides groupis higher than the other two groups in2weeks later(The effective rate ofAcitretin and Tripterygium Glycosides group is92.31%, Acitretin group is64.52%and Tripterygium Glycosides group is62.5%)。 Acitretin and TripterygiumGlycosides group to Acitretin group is X~2=9.092，P=0.028<0.05, there arestatistically significant differences between the two groups; Acitretin and Tripterygium Glycosides group to Tripterygium Glycosides group is X~2=11.084，P=0.011<0.05, there are statistically significant differences between the twogroups; Acitretin group to Tripterygium Glycosides group is X~2=0.575，P=0.902＞0.05, there are no statistically significant differences between the twogroups.Conclusion: Compared to the other two groups，the curative effect ofpalmoplantar pustulosis treated with Acitretin and Tripterygium Glycosides isvery good，and side effect without increased significantly.更多还原